ART5 Gene (ADP-Ribosyltransferase 5)
Comprehensive gene card for ART5, including genomic context, expression, and disease associations.
Gene Information Card
| Symbol | ART5 |
|---|---|
| Full Name | ADP-ribosyltransferase 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 11p15.4 |
| NCBI Gene ID | 116 ncbi.nlm.nih.gov/gene/116 |
| Ensembl ID | ENSG00000167397 |
| UniProt ID | P52961 |
| OMIM ID | 601833 |
| HGNC ID | 727 |
| Aliases | ARTC5, ART5, GPI-ART5 |
Description
ART5 (ADP-ribosyltransferase 5) encodes a glycosylphosphatidylinositol (GPI)-anchored ectoenzyme that catalyzes the transfer of ADP-ribose from NAD+ to arginine residues of target proteins. This gene is part of the ADP-ribosyltransferase family and is primarily expressed in testis and certain immune cells. ART5 has been implicated in immune regulation and cellular signaling.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations in ClinVar or OMIM | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Spleen | 3.2 | Low |
| Lymph node | 2.1 | Low |
| Bone marrow | 1.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.5 | Very low |
| K562 | 0.3 | Very low |
| Jurkat | 1.2 | Low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations in COSMIC or ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • NAD+ ADP-ribosyltransferase activity (GO:0003950) | • protein ADP-ribosylation (GO:0006471) |
| • plasma membrane (GO:0005886) | • cell surface (GO:0009986) |
Pathways
• ADP-ribosylation
• NAD+ metabolism
Protein Summary
ART5 is a GPI-anchored ectoenzyme that transfers ADP-ribose from NAD+ to arginine residues on target proteins. It is involved in post-translational modification and may play a role in immune modulation. The protein is predominantly expressed in testis and lymphoid tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ART5 Knockout HEK293 Cell Line | EDJ-KQ7588 | Human | 116969 | Details Get a Quote |
| ART5 Knockout HCT 116 Cell Line | EDJ-KQ32919 | Human | 116969 | Details Get a Quote |
| ART5 Knockout HeLa Cell Line | EDJ-KQ58001 | Human | 116969 | Details Get a Quote |
| ART5 Knockout A-549 Cell Line | EDJ-KQ66487 | Human | 116969 | Details Get a Quote |
