ARPC5L
Actin Related Protein 2/3 Complex Subunit 5 Like
Gene Information Card
| Symbol | ARPC5L |
|---|---|
| Full Name | Actin Related Protein 2/3 Complex Subunit 5 Like |
| Gene Type | protein-coding |
| Chromosomal Location | 9q33.3 |
| NCBI Gene ID | 81873 ncbi.nlm.nih.gov/gene/81873 |
| Ensembl ID | ENSG00000161981 |
| UniProt ID | Q9BPX5 |
| OMIM ID | 614243 |
| HGNC ID | 28992 |
| Aliases | ARC16, p16-ARC, ARPC5L1 |
Description
ARPC5L encodes a subunit of the actin-related protein 2/3 (ARP2/3) complex, which is essential for actin nucleation and branching. This subunit is a paralog of ARPC5 and contributes to the regulation of actin cytoskeleton dynamics, cell motility, and intracellular transport.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | N/A | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.0 | Low |
| Liver | 4.1 | Low |
| Kidney | 5.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.0 | High expression |
| HeLa | 10.2 | Moderate expression |
| K562 | 7.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Likely loss of function |
| c.100C>T (p.Arg34Trp) | missense | <0.01% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • actin filament polymerization | • ARP2/3 complex-mediated actin nucleation |
| • cytoskeleton organization | • cell migration |
Pathways
• Actin cytoskeleton regulation (Reactome: R-HSA-5663205)
• ARP2/3 complex activation (Reactome: R-HSA-2029482)
Protein Summary
ARPC5L is a 16 kDa protein that forms part of the ARP2/3 complex, which nucleates branched actin filaments. It is structurally similar to ARPC5 and may modulate complex stability or activity in specific cellular contexts.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ARPC5L Knockout HEK293 Cell Line | EDJ-KQ3760 | Human | 81873 | Details Get a Quote |
| ARPC5L Knockout A-549 Cell Line | EDJ-KQ25842 | Human | 81873 | Details Get a Quote |
| ARPC5L Knockout HCT 116 Cell Line | EDJ-KQ25843 | Human | 81873 | Details Get a Quote |
| ARPC5L Knockout HeLa Cell Line | EDJ-KQ25844 | Human | 81873 | Details Get a Quote |
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