ARPC5
Actin Related Protein 2/3 Complex Subunit 5
Gene Information Card
| Symbol | ARPC5 |
|---|---|
| Full Name | Actin Related Protein 2/3 Complex Subunit 5 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q25.3 |
| NCBI Gene ID | 10092 ncbi.nlm.nih.gov/gene/10092 |
| Ensembl ID | ENSG00000162704 |
| UniProt ID | O15511 |
| OMIM ID | 604226 |
| HGNC ID | 705 |
| Aliases | ARC16, p16-ARC, dJ127C7.3 |
Description
ARPC5 encodes a component of the actin-related protein 2/3 (ARP2/3) complex, which is essential for actin nucleation and branching. The complex is composed of seven subunits and regulates actin polymerization, cell motility, and endocytosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Pancreatic cancer | Altered ARPC5 expression may affect cell migration and invasion via ARP2/3 complex dysregulation. | NCBI Gene; COSMIC |
| Breast cancer | Overexpression of ARPC5 correlates with poor prognosis and enhanced metastatic potential. | NCBI Gene; COSMIC |
| Colorectal cancer | ARPC5 upregulation linked to increased cell proliferation and migration. | NCBI Gene; COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 28.5 | High |
| Spleen | 25.3 | High |
| Bone marrow | 22.1 | High |
| Lung | 18.7 | Medium |
| Kidney | 15.2 | Medium |
| Liver | 10.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 32.1 | Embryonic kidney cells |
| HeLa | 28.9 | Cervical cancer cells |
| A549 | 25.4 | Lung carcinoma cells |
| MCF7 | 22.3 | Breast cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | Unknown functional impact |
| c.124C>T | Synonymous | <0.1% | No protein change |
| c.256G>A | Missense | <0.1% | Potential loss of function |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants may impair ARP2/3 complex assembly.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • actin filament polymerization (GO:0030041) | • Arp2/3 complex-mediated actin nucleation (GO:0034314) |
| • plasma membrane (GO:0005886) | • cytoskeleton (GO:0005856) |
| • protein binding (GO:0005515) |
Pathways
• Actin cytoskeleton regulation (KEGG: hsa04810)
• Arp2/3 complex-mediated actin nucleation (Reactome: R-HSA-201688)
Protein Summary
ARPC5 is a 16 kDa subunit of the ARP2/3 complex. It stabilizes the complex and is required for efficient actin nucleation. The protein is ubiquitously expressed and plays a role in cell shape, motility, and vesicle trafficking.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ARPC5L Knockout HEK293 Cell Line | EDJ-KQ3760 | Human | 81873 | Details Get a Quote |
| ARPC5 Knockout HEK293 Cell Line | EDJ-KQ6257 | Human | 10092 | Details Get a Quote |
| ARPC5L Knockout A-549 Cell Line | EDJ-KQ25842 | Human | 81873 | Details Get a Quote |
| ARPC5L Knockout HCT 116 Cell Line | EDJ-KQ25843 | Human | 81873 | Details Get a Quote |
| ARPC5L Knockout HeLa Cell Line | EDJ-KQ25844 | Human | 81873 | Details Get a Quote |
| ARPC5 Knockout A-549 Cell Line | EDJ-KQ31503 | Human | 10092 | Details Get a Quote |
| ARPC5 Knockout HCT 116 Cell Line | EDJ-KQ31505 | Human | 10092 | Details Get a Quote |
| ARPC5 Knockout HeLa Cell Line | EDJ-KQ31506 | Human | 10092 | Details Get a Quote |
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