ARPC4-TTLL3
ARPC4-TTLL3 readthrough transcript
Gene Information Card
| Symbol | ARPC4-TTLL3 |
|---|---|
| Full Name | ARPC4-TTLL3 readthrough (NMD candidate) |
| Gene Type | readthrough transcript (protein-coding) |
| Chromosomal Location | 3p25.3 |
| NCBI Gene ID | 100861540 ncbi.nlm.nih.gov/gene/100861540 |
| Ensembl ID | ENSG00000269335 |
| UniProt ID | Q9BTW9 |
| OMIM ID | - |
| HGNC ID | 44233 |
| Aliases | ARPC4-TTLL3 readthrough transcript |
Description
ARPC4-TTLL3 is a readthrough transcript that spans the ARPC4 and TTLL3 genes on chromosome 3. The resulting mRNA is predicted to undergo nonsense-mediated decay (NMD) and may not produce a stable protein. ARPC4 encodes a component of the Arp2/3 complex involved in actin polymerization, while TTLL3 encodes a tubulin tyrosine ligase involved in tubulin polyglutamylation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No evidence in ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.3 | Low |
| Brain | 0.1 | Low |
| Other tissues | <0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 0.2 | Low expression |
| K562 | 0.1 | Low expression |
| Other cell lines | <0.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants | - | - | - |
Mutation functional classification
Loss of Function (LOF)
Not applicable; no known functional protein.
Gain of Function (GOF)
Not applicable.
Dominant Negative (DN)
Not applicable.
View complete mutation data：
Gene Ontology (GO)
| • No GO terms directly assigned to this readthrough transcript |
Pathways
• No specific pathways associated with this readthrough transcript
Protein Summary
The ARPC4-TTLL3 readthrough transcript is predicted to be a candidate for nonsense-mediated decay, and no stable protein product has been experimentally confirmed. Individual ARPC4 and TTLL3 proteins have well-characterized roles in cytoskeletal dynamics and tubulin modification, respectively.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ARPC4-TTLL3 Knockout HEK293 Cell Line | EDJ-KQ52468 | Human | 100526693 | Details Get a Quote |
| ARPC4-TTLL3 Knockout HeLa Cell Line | EDJ-KQ60931 | Human | 100526693 | Details Get a Quote |
| ARPC4-TTLL3 Knockout A-549 Cell Line | EDJ-KQ69406 | Human | 100526693 | Details Get a Quote |
| ARPC4-TTLL3 Knockout HCT 116 Cell Line | EDJ-KQ77757 | Human | 100526693 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
