ARPC2: Actin-Related Protein 2/3 Complex Subunit 2
Key regulator of actin cytoskeleton dynamics and cell motility
Gene Information Card
| Symbol | ARPC2 |
|---|---|
| Full Name | Actin Related Protein 2/3 Complex Subunit 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q36.1 |
| NCBI Gene ID | 10109 ncbi.nlm.nih.gov/gene/10109 |
| Ensembl ID | ENSG00000163466 |
| UniProt ID | O15144 |
| OMIM ID | 604224 |
| HGNC ID | 704 |
| Aliases | p34-ARC, ARC34, PRO2446 |
Description
ARPC2 encodes the p34 subunit of the actin-related protein 2/3 (ARP2/3) complex, which is essential for actin nucleation and branching. The ARP2/3 complex mediates the formation of branched actin networks, driving cell motility, endocytosis, and intracellular transport. ARPC2 is ubiquitously expressed and its dysregulation is implicated in cancer invasion and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Pancreatic cancer | Overexpression of ARPC2 enhances ARP2/3 complex activity, promoting actin polymerization and invasive cell migration | PMID: 31209238 |
| Breast cancer | ARPC2 upregulation correlates with poor prognosis and increased metastatic potential via lamellipodia formation | PMID: 29367642 |
| Colorectal cancer | ARPC2 knockdown reduces cell proliferation and invasion in vitro | PMID: 30131763 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 28.5 | High |
| Lymph node | 22.1 | High |
| Lung | 18.3 | Medium |
| Brain | 12.7 | Medium |
| Liver | 8.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 35.2 | Cervical cancer cell line |
| A549 | 29.8 | Lung adenocarcinoma cell line |
| MCF7 | 24.1 | Breast cancer cell line |
| HEK293 | 20.5 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.437C>T (p.Thr146Met) | Missense | 0.02% (gnomAD) | Unknown functional impact |
| c.622G>A (p.Glu208Lys) | Missense | 0.01% (gnomAD) | Predicted benign by SIFT |
| c.1A>G (p.Met1Val) | Start loss | Rare | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Start loss mutations (e.g., p.Met1Val) are predicted to abolish protein expression, impairing ARP2/3 complex assembly.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in ARPC2.
Dominant Negative (DN)
No dominant-negative mutations described for ARPC2.
View complete mutation data：
Gene Ontology (GO)
| • actin filament polymerization (GO:0030041) | • plasma membrane (GO:0005886) |
| • cytoskeleton (GO:0005856) | • actin cortical patch (GO:0030479) |
| • protein binding (GO:0005515) |
Pathways
• Actin nucleation by ARP2/3 complex (Reactome: R-HSA-201688)
• Regulation of actin dynamics for phagocytic cup formation (Reactome: R-HSA-2029485)
• CDC42 signaling (Reactome: R-HSA-9013423)
Protein Summary
ARPC2 (p34-ARC) is a 34 kDa core subunit of the ARP2/3 complex, which nucleates branched actin filaments. The protein contains a WD40-like domain that mediates interactions with other complex subunits and regulatory factors. ARPC2 is essential for complex stability and localization to the leading edge of migrating cells.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ARPC2 Knockout HEK293 Cell Line | EDJ-KQ3505 | Human | 10109 | Details Get a Quote |
| ARPC2 Knockout A-549 Cell Line | EDJ-KQ18147 | Human | 10109 | Details Get a Quote |
| ARPC2 Knockout HCT 116 Cell Line | EDJ-KQ25316 | Human | 10109 | Details Get a Quote |
| ARPC2 Knockout HeLa Cell Line | EDJ-KQ25317 | Human | 10109 | Details Get a Quote |
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