ARPC1A
Actin Related Protein 2/3 Complex Subunit 1A
Gene Information Card
| Symbol | ARPC1A |
|---|---|
| Full Name | Actin Related Protein 2/3 Complex Subunit 1A |
| Gene Type | protein-coding |
| Chromosomal Location | 7q22.1 |
| NCBI Gene ID | 10552 ncbi.nlm.nih.gov/gene/10552 |
| Ensembl ID | ENSG00000106333 |
| UniProt ID | O15143 |
| OMIM ID | 604220 |
| HGNC ID | 703 |
| Aliases | SOP2Hs, p41-ARC, ARC40 |
Description
ARPC1A encodes subunit 1A of the actin-related protein 2/3 (ARP2/3) complex, which is essential for actin nucleation and branching. This complex regulates actin cytoskeleton dynamics, influencing cell shape, motility, and intracellular transport. ARPC1A is ubiquitously expressed and plays a role in cancer cell invasion and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Pancreatic cancer | Overexpression of ARPC1A enhances ARP2/3 complex activity, promoting cell migration and invasion. | PMID: 25605247 |
| Breast cancer | ARPC1A upregulation correlates with poor prognosis and increased metastatic potential. | PMID: 29367642 |
| Colorectal cancer | ARPC1A amplification contributes to cytoskeletal remodeling and tumor progression. | PMID: 31092904 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 10.2 | Medium |
| Testis | 15.8 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.2 | Cervical cancer cell line |
| A549 | 9.7 | Lung cancer cell line |
| MCF7 | 11.5 | Breast cancer cell line |
| HepG2 | 7.8 | Liver cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287G>A (p.Arg96His) | Missense | <0.01% | Unknown functional impact; reported in COSMIC |
| c.523C>T (p.Arg175Trp) | Missense | <0.01% | Potential loss of function; observed in cancer samples |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants may disrupt ARP2/3 complex assembly, reducing actin nucleation.
Gain of Function (GOF)
Not well characterized; overexpression is more common than activating mutations.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • actin cytoskeleton organization | • actin filament polymerization |
| • ARP2/3 complex-mediated actin nucleation | • cell migration |
| • cell division |
Pathways
• Actin cytoskeleton regulation (KEGG: hsa04810)
• Fc gamma R-mediated phagocytosis (KEGG: hsa04666)
• Regulation of actin dynamics for phagocytic cup formation
Protein Summary
ARPC1A is a 40 kDa subunit of the ARP2/3 complex, which nucleates branched actin filaments. It contains a WD40 domain that mediates protein-protein interactions. The protein is localized in the cytoplasm and at the leading edge of migrating cells.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ARPC1A Knockout HEK293 Cell Line | EDJ-KQ50986 | Human | 10552 | Details Get a Quote |
| ARPC1A Knockout HeLa Cell Line | EDJ-KQ55428 | Human | 10552 | Details Get a Quote |
| ARPC1A Knockout A-549 Cell Line | EDJ-KQ63908 | Human | 10552 | Details Get a Quote |
| ARPC1A Knockout HCT 116 Cell Line | EDJ-KQ72368 | Human | 10552 | Details Get a Quote |
