ARMH3 Gene - Armadillo Like Helical Domain Containing 3
Comprehensive genomic and proteomic analysis of ARMH3, a gene encoding a protein with armadillo-type fold involved in cellular processes.
Gene Information Card
| Symbol | ARMH3 |
|---|---|
| Full Name | Armadillo Like Helical Domain Containing 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 10q22.3 |
| NCBI Gene ID | 123688 ncbi.nlm.nih.gov/gene/123688 |
| Ensembl ID | ENSG00000165832 |
| UniProt ID | Q8N7H5 |
| OMIM ID | 618089 |
| HGNC ID | 25707 |
| Aliases | FLJ12529, dJ1181N3.1 |
Description
ARMH3 (Armadillo Like Helical Domain Containing 3) is a protein-coding gene located on chromosome 10q22.3. The encoded protein contains an armadillo-type fold, which is often involved in protein-protein interactions and cellular signaling. ARMH3 is expressed in various tissues and may play a role in cellular architecture and transport processes. Limited functional studies are available, and its precise biological role remains under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.3 | Low |
| Lung | 6.1 | Low |
| Liver | 4.7 | Low |
| Kidney | 5.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.2 | Embryonic kidney cells |
| HeLa | 7.8 | Cervical carcinoma cells |
| K562 | 6.5 | Leukemia cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function variants in ClinVar or COSMIC.
Gain of Function (GOF)
No documented gain-of-function variants.
Dominant Negative (DN)
No documented dominant-negative variants.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • cytoplasm (GO:0005737) |
Pathways
• No curated pathways in Reactome or KEGG
Protein Summary
The ARMH3 protein (UniProt Q8N7H5) is 746 amino acids long and contains an armadillo-like helical domain. Armadillo repeats typically mediate protein-protein interactions. The protein is predicted to localize to the cytoplasm. Its exact function is not fully characterized, but it may be involved in intracellular transport or signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ARMH3 Knockout HEK293 Cell Line | EDJ-KQ12437 | Human | 79591 | Details Get a Quote |
| ARMH3 Knockout A-549 Cell Line | EDJ-KQ41363 | Human | 79591 | Details Get a Quote |
| ARMH3 Knockout HCT 116 Cell Line | EDJ-KQ41364 | Human | 79591 | Details Get a Quote |
| ARMH3 Knockout HeLa Cell Line | EDJ-KQ41365 | Human | 79591 | Details Get a Quote |
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