ARL4A
ADP Ribosylation Factor Like GTPase 4A
Gene Information Card
| Symbol | ARL4A |
|---|---|
| Full Name | ADP Ribosylation Factor Like GTPase 4A |
| Gene Type | protein-coding |
| Chromosomal Location | 7p21.3 |
| NCBI Gene ID | 10124 ncbi.nlm.nih.gov/gene/10124 |
| Ensembl ID | ENSG00000122644 |
| UniProt ID | P40617 |
| OMIM ID | 604786 |
| HGNC ID | 695 |
| Aliases | ARL4, ARL4A, ARL4A1 |
Description
ARL4A (ADP Ribosylation Factor Like GTPase 4A) is a member of the ARF-like family of small GTPases. It is involved in intracellular vesicle trafficking, cytoskeletal organization, and cell signaling. The gene is located on chromosome 7p21.3 and encodes a 200-amino acid protein. ARL4A is widely expressed in various tissues and has been implicated in cancer and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | ARL4A overexpression may promote cell proliferation and migration through altered GTPase signaling. | COSMIC; literature |
| Developmental disorders | Potential role in ciliary function and embryonic development. | OMIM; literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Thyroid | 12.8 | Medium |
| Adrenal gland | 11.5 | Medium |
| Brain | 8.3 | Low |
| Liver | 6.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 18.5 | High expression |
| HeLa | 14.2 | Medium expression |
| A549 | 12.0 | Medium expression |
| MCF7 | 9.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T | missense | <0.1% | p.Thr41Ile; unknown significance |
| c.456G>A | missense | <0.1% | p.Val152Met; unknown significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • GTP binding | • GTPase activity |
| • intracellular protein transport | • vesicle-mediated transport |
| • cilium assembly |
Pathways
• Vesicle-mediated transport
• ARF family signaling
Protein Summary
ARL4A is a small GTPase that cycles between an active GTP-bound and inactive GDP-bound state. It regulates membrane trafficking and cytoskeletal dynamics. The protein localizes to the Golgi apparatus and cilia, and its expression is associated with cell proliferation and migration.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ARL4A Knockout HEK293 Cell Line | EDJ-KQ50933 | Human | 10124 | Details Get a Quote |
| ARL4A Knockout HeLa Cell Line | EDJ-KQ55324 | Human | 10124 | Details Get a Quote |
| ARL4A Knockout A-549 Cell Line | EDJ-KQ63806 | Human | 10124 | Details Get a Quote |
| ARL4A Knockout HCT 116 Cell Line | EDJ-KQ72264 | Human | 10124 | Details Get a Quote |
