ARL16: ADP Ribosylation Factor Like GTPase 16
A small GTPase involved in intracellular trafficking and potential tumor suppression
Gene Information Card
| Symbol | ARL16 |
|---|---|
| Full Name | ADP Ribosylation Factor Like GTPase 16 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q21.31 |
| NCBI Gene ID | 339231 ncbi.nlm.nih.gov/gene/339231 |
| Ensembl ID | ENSG00000187764 |
| UniProt ID | Q5T0J0 |
| OMIM ID | 618183 |
| HGNC ID | 23081 |
| Aliases | FLJ38973, MGC26803 |
Description
ARL16 (ADP Ribosylation Factor Like GTPase 16) is a member of the ARF family of small GTPases. It is involved in intracellular vesicle trafficking, particularly in the retrograde transport from endosomes to the Golgi apparatus. The gene is located on chromosome 17q21.31 and encodes a 200-amino acid protein. ARL16 has been implicated in cellular processes including cytokinesis and may play a role in tumor suppression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Potential tumor suppressor; altered expression or mutation may contribute to oncogenesis | COSMIC database reports somatic mutations in multiple cancer types |
| No specific Mendelian disease associated | Not yet established | OMIM lists no disease association as of current curation |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Thyroid | 8.1 | Medium |
| Adrenal gland | 7.5 | Medium |
| Brain | 6.2 | Low |
| Lung | 5.4 | Low |
| Liver | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.1 | Embryonic kidney cells |
| HeLa | 8.7 | Cervical cancer cells |
| A549 | 7.3 | Lung cancer cells |
| MCF7 | 6.9 | Breast cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| p.Gly56Arg | Missense | <0.1% | Unknown functional impact |
| p.Arg97Trp | Missense | <0.1% | Unknown functional impact |
| p.Glu123Lys | Missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
Not established; no confirmed loss-of-function mutations reported in literature or curated databases.
Gain of Function (GOF)
Not established; no confirmed gain-of-function mutations reported.
Dominant Negative (DN)
Not established; no confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • GTP binding | • GTPase activity |
| • intracellular protein transport | • Golgi to endosome transport |
| • cytokinesis |
Pathways
• Vesicle-mediated transport
• ARF family signaling
Protein Summary
ARL16 is a small GTPase of the ARF-like family. It cycles between an inactive GDP-bound and active GTP-bound form, regulating membrane trafficking events. The protein localizes to the Golgi apparatus and endosomes, and is involved in retrograde transport. Its precise cellular functions are still under investigation, but it may contribute to cell division and tumor suppression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ARL16 Knockout HEK293 Cell Line | EDJ-KQ12430 | Human | 339231 | Details Get a Quote |
| ARL16 Knockout A-549 Cell Line | EDJ-KQ41348 | Human | 339231 | Details Get a Quote |
| ARL16 Knockout HCT 116 Cell Line | EDJ-KQ41349 | Human | 339231 | Details Get a Quote |
| ARL16 Knockout HeLa Cell Line | EDJ-KQ41350 | Human | 339231 | Details Get a Quote |
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