ARHGEF26
Rho Guanine Nucleotide Exchange Factor 26
Gene Information Card
| Symbol | ARHGEF26 |
|---|---|
| Full Name | Rho Guanine Nucleotide Exchange Factor 26 |
| Gene Type | protein-coding |
| Chromosomal Location | 3q26.31 |
| NCBI Gene ID | 26084 ncbi.nlm.nih.gov/gene/26084 |
| Ensembl ID | ENSG00000114739 |
| UniProt ID | Q96DR7 |
| OMIM ID | 617884 |
| HGNC ID | 25586 |
| Aliases | SGEF, FLJ00068 |
Description
ARHGEF26 (Rho Guanine Nucleotide Exchange Factor 26) encodes a protein that activates Rho GTPases by exchanging GDP for GTP. It is involved in cytoskeletal reorganization, cell migration, and adhesion. Overexpression is linked to cancer progression and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Promotes cell migration and invasion via RhoA activation | COSMIC, NCBI |
| Breast Cancer | Upregulated; enhances metastatic potential | NCBI, UniProt |
| Gastric Cancer | Associated with poor prognosis and tumor growth | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Colon | 15.2 | Medium |
| Breast | 6.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.4 | Cervical cancer line |
| A549 | 22.1 | Lung cancer line |
| MCF7 | 9.8 | Breast cancer line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.124G>A | Missense | 0.02% | p.Glu42Lys; uncertain significance |
| c.856C>T | Nonsense | <0.01% | p.Arg286*; loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., p.Arg286*) lead to truncated protein and loss of GEF activity.
Gain of Function (GOF)
Missense mutations in the DH domain may increase RhoA activation, promoting oncogenic signaling.
Dominant Negative (DN)
Not reported in ARHGEF26.
View complete mutation data：
Gene Ontology (GO)
| • Rho guanyl-nucleotide exchange factor activity | • GTPase activator activity |
| • cytoskeleton organization | • cell migration |
| • signal transduction |
Pathways
• Rho GTPase cycle
• Signaling by Rho family GTPases
• Axon guidance
Protein Summary
ARHGEF26 (SGEF) is a 748-amino acid protein containing a Dbl homology (DH) domain and a pleckstrin homology (PH) domain. It specifically activates RhoA and RhoC, regulating actin dynamics and cell motility. Localizes to the plasma membrane and is implicated in cancer cell invasion.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ARHGEF26 Knockout HEK293 Cell Line | EDJ-KQ8391 | Human | 26084 | Details Get a Quote |
| ARHGEF26 Knockout HeLa Cell Line | EDJ-KQ33122 | Human | 26084 | Details Get a Quote |
| ARHGEF26 Knockout A-549 Cell Line | EDJ-KQ34455 | Human | 26084 | Details Get a Quote |
| ARHGEF26 Knockout HCT 116 Cell Line | EDJ-KQ34456 | Human | 26084 | Details Get a Quote |
