ARHGDIG
Rho GDP Dissociation Inhibitor Gamma
Gene Information Card
| Symbol | ARHGDIG |
|---|---|
| Full Name | Rho GDP dissociation inhibitor gamma |
| Gene Type | Protein coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 398 ncbi.nlm.nih.gov/gene/398 |
| Ensembl ID | ENSG00000161921 |
| UniProt ID | Q92575 |
| OMIM ID | 602844 |
| HGNC ID | 678 |
| Aliases | RhoGDI3, RhoGDI gamma, GDI-3 |
Description
ARHGDIG encodes Rho GDP dissociation inhibitor gamma (RhoGDI3), a member of the RhoGDI family that regulates Rho GTPase signaling by inhibiting GDP dissociation and controlling subcellular localization. RhoGDI3 is predominantly expressed in brain and pancreas and plays roles in cytoskeletal dynamics, cell migration, and vesicular trafficking. Altered expression is linked to cancer progression and neurological disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Dysregulation of Rho GTPase signaling via altered ARHGDIG expression affects cell migration and invasion. | NCBI Gene, COSMIC |
| Intellectual disability | Rare variants in ARHGDIG may disrupt neuronal Rho signaling. | ClinVar, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Pancreas | 8.3 | Low |
| Testis | 6.1 | Low |
| Lung | 2.4 | Not detected |
| Liver | 1.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 15.2 | High expression |
| HeLa (cervical) | 3.8 | Low expression |
| HEK293 (embryonic kidney) | 2.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.205C>T (p.Arg69Trp) | Missense | <0.01% | Unknown functional impact; reported in ClinVar |
| c.340G>A (p.Glu114Lys) | Missense | <0.01% | Predicted benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative variants described.
View complete mutation data：
Gene Ontology (GO)
| • Rho GDP-dissociation inhibitor activity | • GTPase activator activity |
| • cytosol | • cytoplasm |
| • plasma membrane | • regulation of cell migration |
| • signal transduction |
Pathways
• Rho GTPase cycle
• Signaling by Rho family GTPases
• RhoGDI pathway
Protein Summary
Rho GDP dissociation inhibitor gamma (RhoGDI3) is a 225-amino acid protein that binds prenylated Rho GTPases, inhibiting GDP release and sequestering them in the cytosol. It is highly expressed in brain and pancreas, where it modulates actin dynamics and intracellular trafficking. Structural studies show a conserved N-terminal regulatory domain and a C-terminal immunoglobulin-like domain.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ARHGDIG Knockout HEK293 Cell Line | EDJ-KQ4088 | Human | 398 | Details Get a Quote |
| ARHGDIG Knockout A-549 Cell Line | EDJ-KQ26473 | Human | 398 | Details Get a Quote |
| ARHGDIG Knockout HeLa Cell Line | EDJ-KQ52658 | Human | 398 | Details Get a Quote |
| ARHGDIG Knockout HCT 116 Cell Line | EDJ-KQ69618 | Human | 398 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
