ARHGAP21
Rho GTPase Activating Protein 21
Gene Information Card
| Symbol | ARHGAP21 |
|---|---|
| Full Name | Rho GTPase Activating Protein 21 |
| Gene Type | protein-coding |
| Chromosomal Location | 10p12.1 |
| NCBI Gene ID | 57584 ncbi.nlm.nih.gov/gene/57584 |
| Ensembl ID | ENSG00000107968 |
| UniProt ID | Q5T5U3 |
| OMIM ID | 608854 |
| HGNC ID | 24022 |
| Aliases | ARHGAP10, FLJ10970, KIAA1424, RhoGAP21 |
Description
ARHGAP21 (Rho GTPase Activating Protein 21) encodes a member of the RhoGAP family of proteins that catalyze the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thereby negatively regulating Rho-mediated signaling. The protein is involved in cytoskeletal organization, cell migration, and adhesion. ARHGAP21 has been implicated in cancer progression and neurodevelopmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered expression or mutation may disrupt Rho signaling, promoting cell migration and invasion. | PMID: 23431137, COSMIC |
| Neurodevelopmental disorders | Potential role in neuronal migration and differentiation; rare variants reported. | ClinVar, PMID: 27545674 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 9.7 | Low |
| Testis | 15.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 10.4 | Cervical cancer cell line |
| HEK 293 | 8.9 | Embryonic kidney cells |
| K562 | 7.2 | Leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.1% | Loss of function; truncation |
| c.567G>A (p.Trp189*) | Nonsense | <0.1% | Loss of function; truncation |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations leading to premature stop codons and truncated protein.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • Rho GTPase activator activity | • GTPase activator activity |
| • cytoskeleton | • cell migration |
| • cell adhesion | • cytoplasm |
| • plasma membrane |
Pathways
• Rho GTPase cycle
• Signaling by Rho GTPases
• Regulation of actin cytoskeleton
Protein Summary
ARHGAP21 is a 1048-amino acid protein containing a RhoGAP domain that inactivates RhoA, Rac1, and Cdc42. It localizes to the cytoplasm and plasma membrane, regulating actin dynamics and cell motility. The protein interacts with several partners including PKC and FAK, influencing cell adhesion and migration.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ARHGAP21 Knockout HEK293 Cell Line | EDJ-KQ11685 | Human | 57584 | Details Get a Quote |
| ARHGAP21 Knockout A-549 Cell Line | EDJ-KQ41305 | Human | 57584 | Details Get a Quote |
| ARHGAP21 Knockout HCT 116 Cell Line | EDJ-KQ41307 | Human | 57584 | Details Get a Quote |
| ARHGAP21 Knockout HeLa Cell Line | EDJ-KQ41308 | Human | 57584 | Details Get a Quote |
