ARHGAP19
Rho GTPase Activating Protein 19
Gene Information Card
| Symbol | ARHGAP19 |
|---|---|
| Full Name | Rho GTPase Activating Protein 19 |
| Gene Type | protein-coding |
| Chromosomal Location | 10q24.1 |
| NCBI Gene ID | 84986 ncbi.nlm.nih.gov/gene/84986 |
| Ensembl ID | ENSG00000165801 |
| UniProt ID | Q8N264 |
| OMIM ID | 610586 |
| HGNC ID | 24053 |
| Aliases | FLJ11273, MGC131893 |
Description
ARHGAP19 (Rho GTPase Activating Protein 19) is a protein-coding gene located on chromosome 10q24.1. It encodes a member of the Rho GTPase-activating protein family, which negatively regulates Rho GTPases by accelerating GTP hydrolysis, thereby modulating cytoskeletal dynamics, cell migration, and proliferation. The gene is expressed in various tissues and is implicated in cancer and immune regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered expression may disrupt Rho GTPase signaling, affecting cell migration and invasion | COSMIC database reports somatic mutations in multiple cancer types |
| Immunodeficiency | Potential role in lymphocyte migration and activation | Limited evidence from functional studies |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.3 | Medium |
| Bone marrow | 8.7 | Low |
| Lung | 6.2 | Low |
| Brain | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | Moderate expression |
| HeLa | 8.5 | Low expression |
| K562 | 12.0 | Moderate expression |
| MCF7 | 5.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown functional impact |
| c.250G>A (p.Gly84Ser) | Missense | <0.01% | Reported in COSMIC for colorectal cancer |
Mutation functional classification
Loss of Function (LOF)
Not established; some missense variants may reduce GAP activity.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • GTPase activator activity | • Rho GTPase binding |
| • cytosol | • plasma membrane |
| • signal transduction |
Pathways
• Rho GTPase cycle
• Signaling by Rho GTPases
Protein Summary
ARHGAP19 encodes a Rho GTPase-activating protein (GAP) that inactivates Rho family GTPases by stimulating GTP hydrolysis. The protein localizes to the cytosol and plasma membrane, regulating actin cytoskeleton reorganization, cell shape, and motility. It is expressed in lymphoid tissues and may play a role in immune cell trafficking and cancer metastasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ARHGAP19 Knockout HEK293 Cell Line | EDJ-KQ10294 | Human | 84986 | Details Get a Quote |
| ARHGAP19 Knockout HCT 116 Cell Line | EDJ-KQ36313 | Human | 84986 | Details Get a Quote |
| ARHGAP19 Knockout A-549 Cell Line | EDJ-KQ37563 | Human | 84986 | Details Get a Quote |
| ARHGAP19 Knockout HeLa Cell Line | EDJ-KQ37565 | Human | 84986 | Details Get a Quote |
