ARHGAP10
Rho GTPase Activating Protein 10
Gene Information Card
| Symbol | ARHGAP10 |
|---|---|
| Full Name | Rho GTPase Activating Protein 10 |
| Gene Type | protein-coding |
| Chromosomal Location | 4q31.23 |
| NCBI Gene ID | 79658 ncbi.nlm.nih.gov/gene/79658 |
| Ensembl ID | ENSG00000164171 |
| UniProt ID | A1A4S6 |
| OMIM ID | 609746 |
| HGNC ID | 24050 |
| Aliases | GRAF2, PS-GAP, RhoGAP10 |
Description
ARHGAP10 encodes a member of the Rho GTPase-activating protein (RhoGAP) family. The protein contains an N-terminal SEC14 domain, a pleckstrin homology (PH) domain, and a C-terminal RhoGAP domain. It functions as a GTPase activator for RhoA and Cdc42, converting them to the inactive GDP-bound state, thereby regulating cytoskeletal reorganization, cell migration, and adhesion.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered expression may affect Rho signaling and cell motility | COSMIC; NCBI Gene |
| Colorectal cancer | Mutations and copy number alterations reported | COSMIC |
| Lung cancer | Somatic mutations observed | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 8.2 | Medium |
| Heart | 5.1 | Low |
| Liver | 3.4 | Low |
| Lung | 6.7 | Medium |
| Kidney | 4.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 12.3 | Moderate expression |
| HeLa | 9.8 | Moderate expression |
| A549 | 7.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | missense | 0.02% | p.Pro412Ser; unknown functional impact |
| c.567_568del | frameshift deletion | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift or nonsense mutations that truncate the RhoGAP domain are predicted to impair GTPase activation.
Gain of Function (GOF)
Not well characterized; no recurrent activating mutations reported.
Dominant Negative (DN)
Mutations in the GAP domain may produce dominant-negative effects by sequestering Rho GTPases.
View complete mutation data：
Gene Ontology (GO)
| • GTPase activator activity | • Rho GTPase binding |
| • cytosol | • plasma membrane |
| • regulation of cell migration | • actin cytoskeleton organization |
Pathways
• Rho GTPase cycle
• Signaling by Rho GTPases
• Regulation of actin dynamics
Protein Summary
ARHGAP10 is a 779-amino acid protein that acts as a GTPase-activating protein (GAP) for RhoA and Cdc42. It localizes to the plasma membrane and cytosol, and is involved in regulating actin cytoskeleton dynamics, cell spreading, and focal adhesion turnover. The SEC14 domain may mediate lipid binding.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ARHGAP10 Knockout HEK293 Cell Line | EDJ-KQ11677 | Human | 79658 | Details Get a Quote |
| ARHGAP10 Knockout A-549 Cell Line | EDJ-KQ41298 | Human | 79658 | Details Get a Quote |
| ARHGAP10 Knockout HCT 116 Cell Line | EDJ-KQ41300 | Human | 79658 | Details Get a Quote |
| ARHGAP10 Knockout HeLa Cell Line | EDJ-KQ41301 | Human | 79658 | Details Get a Quote |
