APOBEC4
Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide Like 4
Gene Information Card
| Symbol | APOBEC4 |
|---|---|
| Full Name | Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide Like 4 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q25.3 |
| NCBI Gene ID | 403314 ncbi.nlm.nih.gov/gene/403314 |
| Ensembl ID | ENSG00000189227 |
| UniProt ID | Q8WW27 |
| OMIM ID | 613358 |
| HGNC ID | 24552 |
| Aliases | C1orf150, FLJ25663 |
Description
APOBEC4 (Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide Like 4) is a protein-coding gene belonging to the APOBEC family of cytidine deaminases. The encoded protein is predicted to have zinc-dependent deaminase activity, though its exact biological function remains incompletely characterized. APOBEC4 is primarily expressed in testis and may play a role in nucleic acid editing or innate immunity.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations established | Not applicable | No curated disease entries in OMIM, ClinVar, or COSMIC as of current data |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 3.1 | Low |
| Thyroid | 0.6 | Not detected |
| Prostate | 0.5 | Not detected |
| Lung | 0.4 | Not detected |
| Kidney | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.2 | Low expression |
| HeLa | 0.1 | Not detected |
| K562 | 0.1 | Not detected |
| MCF7 | 0.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No loss-of-function mutations reported in curated databases.
Gain of Function (GOF)
No gain-of-function mutations reported in curated databases.
Dominant Negative (DN)
No dominant-negative mutations reported in curated databases.
View complete mutation data：
Gene Ontology (GO)
| • cytidine deaminase activity (GO:0004126) | • zinc ion binding (GO:0008270) |
| • nucleic acid binding (GO:0003676) |
Pathways
• No curated pathways in Reactome or KEGG for APOBEC4
Protein Summary
APOBEC4 is a 367-amino acid protein with a conserved cytidine deaminase domain. It is predicted to localize to the nucleus and may function in RNA or DNA editing. Structural studies suggest it binds zinc ions essential for catalytic activity. Unlike other APOBEC family members, APOBEC4 has not been linked to antiviral activity or cancer mutagenesis in current literature.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| APOBEC4 Knockout HEK293 Cell Line | EDJ-KQ11694 | Human | 403314 | Details Get a Quote |
| APOBEC4 Knockout HeLa Cell Line | EDJ-KQ60341 | Human | 403314 | Details Get a Quote |
| APOBEC4 Knockout A-549 Cell Line | EDJ-KQ68808 | Human | 403314 | Details Get a Quote |
| APOBEC4 Knockout HCT 116 Cell Line | EDJ-KQ77171 | Human | 403314 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
