ANXA3 (Annexin A3) Gene
A member of the annexin family involved in membrane trafficking, calcium signaling, and cancer progression.
Gene Information Card
| Symbol | ANXA3 |
|---|---|
| Full Name | Annexin A3 |
| Gene Type | Protein coding |
| Chromosomal Location | 4q21.21 |
| NCBI Gene ID | 306 ncbi.nlm.nih.gov/gene/306 |
| Ensembl ID | ENSG00000138772 |
| UniProt ID | P12429 |
| OMIM ID | 106490 |
| HGNC ID | 542 |
| Aliases | ANX3, annexin III, 35-alpha calcimedulin, lipocortin III |
Description
ANXA3 (Annexin A3) encodes a member of the annexin family of calcium-dependent phospholipid-binding proteins. The protein is involved in membrane trafficking, signal transduction, and regulation of cell growth. It is expressed in various tissues and has been implicated in cancer, inflammation, and coagulation disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Overexpression promotes tumor growth and metastasis via PI3K/AKT pathway activation | PMID: 25636847 |
| Acute myeloid leukemia | ANXA3 expression correlates with poor prognosis and chemoresistance | PMID: 27323851 |
| Rheumatoid arthritis | ANXA3 modulates inflammatory cytokine release in synovial fibroblasts | PMID: 19732725 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Liver | 8.3 | Medium |
| Kidney | 15.2 | High |
| Placenta | 20.1 | High |
| Heart | 4.6 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung cancer) | 18.7 | High expression |
| HepG2 (liver cancer) | 9.2 | Moderate expression |
| HEK293 (embryonic kidney) | 6.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.187G>A (p.Gly63Arg) | Missense | 0.02% | Unknown functional impact |
| c.421C>T (p.Arg141Trp) | Missense | 0.01% | Reported in COSMIC database |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
Overexpression in tumors suggests potential gain-of-function role in oncogenesis.
Dominant Negative (DN)
Not documented.
View complete mutation data：
Gene Ontology (GO)
| • calcium ion binding (GO:0005509) | • calcium-dependent phospholipid binding (GO:0005544) |
| • membrane (GO:0016020) | • cytoplasm (GO:0005737) |
| • apoptotic process (GO:0006915) |
Pathways
• PI3K-Akt signaling pathway
• Phospholipid binding and membrane trafficking
Protein Summary
Annexin A3 is a 323-amino acid protein (36 kDa) that binds phospholipids in a calcium-dependent manner. It is involved in exocytosis, endocytosis, and regulation of ion channels. The protein is overexpressed in several cancers and may serve as a biomarker for diagnosis and prognosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ANXA3 Knockout HEK293 Cell Line | EDJ-KQ4054 | Human | 306 | Details Get a Quote |
| ANXA3 Knockout A-549 Cell Line | EDJ-KQ26411 | Human | 306 | Details Get a Quote |
| ANXA3 Knockout HCT 116 Cell Line | EDJ-KQ26412 | Human | 306 | Details Get a Quote |
| ANXA3 Knockout HeLa Cell Line | EDJ-KQ26413 | Human | 306 | Details Get a Quote |
