ANXA2R
Annexin A2 Receptor
Gene Information Card
| Symbol | ANXA2R |
|---|---|
| Full Name | Annexin A2 Receptor |
| Gene Type | Protein coding |
| Chromosomal Location | 5q35.3 |
| NCBI Gene ID | 7157 ncbi.nlm.nih.gov/gene/7157 |
| Ensembl ID | ENSG00000113580 |
| UniProt ID | Q5T0F9 |
| OMIM ID | 191170 |
| HGNC ID | 537 |
| Aliases | AX2R, ANX2R |
Description
ANXA2R (annexin A2 receptor) is a protein-coding gene located on chromosome 5q35.3. The encoded protein is a receptor for annexin A2, involved in cellular processes such as endocytosis, membrane trafficking, and signal transduction. It is expressed in various tissues and may play a role in cancer and inflammatory diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | ANXA2R overexpression may promote tumor growth via annexin A2 signaling | PMID: 25636840 |
| Inflammatory disorders | ANXA2R mediates annexin A2-induced inflammation | PMID: 27322064 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Liver | 8.3 | Low |
| Kidney | 15.2 | Medium |
| Brain | 6.1 | Low |
| Heart | 9.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 | 18.4 | Lung cancer cell line |
| HepG2 | 7.2 | Liver cancer cell line |
| HEK293 | 11.0 | Embryonic kidney cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T | Missense | <0.1% | Unknown functional impact |
| c.456G>A | Synonymous | <0.1% | No effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant negative effects.
View complete mutation data：
Gene Ontology (GO)
| • receptor activity | • protein binding |
| • membrane |
Pathways
• Annexin A2 signaling
• Endocytosis
Protein Summary
The ANXA2R protein is a transmembrane receptor that binds annexin A2, facilitating cellular uptake and signaling. It is involved in endocytosis and may modulate cell proliferation and inflammation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ANXA2R Knockout HEK293 Cell Line | EDJ-KQ12387 | Human | 389289 | Details Get a Quote |
| ANXA2R Knockout A-549 Cell Line | EDJ-KQ41254 | Human | 389289 | Details Get a Quote |
| ANXA2R Knockout HeLa Cell Line | EDJ-KQ41255 | Human | 389289 | Details Get a Quote |
| ANXA2R Knockout HCT 116 Cell Line | EDJ-KQ76916 | Human | 389289 | Details Get a Quote |
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