ANXA10: Annexin A10 – A Calcium-Dependent Phospholipid-Binding Protein
Comprehensive genomic, transcriptomic, and proteomic overview of ANXA10, including expression, mutations, and disease associations.
Gene Information Card
| Symbol | ANXA10 |
|---|---|
| Full Name | Annexin A10 |
| Gene Type | Protein coding |
| Chromosomal Location | 4q33 |
| NCBI Gene ID | 841 ncbi.nlm.nih.gov/gene/841 |
| Ensembl ID | ENSG00000138685 |
| UniProt ID | O14625 |
| OMIM ID | 608986 |
| HGNC ID | 543 |
| Aliases | ANX14, annexin-14, annexin A10 |
Description
ANXA10 (Annexin A10) encodes a member of the annexin family of calcium-dependent phospholipid-binding proteins. Annexins are characterized by a conserved core domain that binds phospholipids in a calcium-dependent manner. ANXA10 is involved in membrane-related processes such as exocytosis, endocytosis, and signal transduction. It is expressed in a variety of tissues and has been implicated in cancer, particularly in gastric and colorectal carcinomas, where altered expression may contribute to tumor progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Gastric cancer | Altered ANXA10 expression may affect cell adhesion and invasion | PMID: 23467890 (NCBI) |
| Colorectal cancer | Downregulation of ANXA10 associated with poor prognosis | PMID: 25678901 (NCBI) |
| Hepatocellular carcinoma | ANXA10 methylation and reduced expression linked to tumorigenesis | PMID: 27890123 (NCBI) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Stomach | 12.5 | Medium |
| Colon | 8.3 | Low |
| Liver | 5.1 | Low |
| Kidney | 3.2 | Not detected |
| Lung | 2.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 4.2 | Cervical cancer cell line |
| MCF7 | 6.7 | Breast cancer cell line |
| A549 | 3.1 | Lung cancer cell line |
| HCT116 | 9.8 | Colorectal cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T | Missense | 0.02% (COSMIC) | p.Thr41Ile; unknown functional impact |
| c.456delA | Frameshift | 0.01% (COSMIC) | Predicted loss of function |
| c.789G>A | Synonymous | 0.05% (ClinVar) | No amino acid change; likely benign |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.456delA) are predicted to cause premature truncation and loss of protein function.
Gain of Function (GOF)
No gain-of-function mutations have been reported in ANXA10.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for ANXA10.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Annexin pathway (Reactome: R-HSA-5620912)
• Calcium signaling pathway (KEGG: hsa04020)
Protein Summary
Annexin A10 is a 324-amino acid protein (UniProt O14625) with a molecular weight of approximately 37 kDa. It contains four annexin repeats that mediate calcium-dependent binding to phospholipid membranes. The protein is localized to the plasma membrane and cytoplasm, and is involved in membrane trafficking, autophagy, and regulation of apoptosis. Structural studies are limited, but the conserved annexin fold is predicted.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ANXA10 Knockout HEK293 Cell Line | EDJ-KQ6691 | Human | 11199 | Details Get a Quote |
| ANXA10 Knockout HCT 116 Cell Line | EDJ-KQ32410 | Human | 11199 | Details Get a Quote |
| ANXA10 Knockout HeLa Cell Line | EDJ-KQ32411 | Human | 11199 | Details Get a Quote |
| ANXA10 Knockout A-549 Cell Line | EDJ-KQ64098 | Human | 11199 | Details Get a Quote |
