ANP32E
Acidic Nuclear Phosphoprotein 32 Family Member E
Gene Information Card
| Symbol | ANP32E |
|---|---|
| Full Name | Acidic Nuclear Phosphoprotein 32 Family Member E |
| Gene Type | Protein coding |
| Chromosomal Location | 1q21.3 |
| NCBI Gene ID | 81611 ncbi.nlm.nih.gov/gene/81611 |
| Ensembl ID | ENSG00000143401 |
| UniProt ID | Q9BTT0 |
| OMIM ID | 606836 |
| HGNC ID | 24032 |
| Aliases | LANP-L, LANPL, MGC129616, MGC129617 |
Description
ANP32E encodes a member of the acidic nuclear phosphoprotein 32 family, which functions as a histone chaperone. The protein specifically replaces histone H2A.Z/H2B dimers from nucleosomes, regulating chromatin dynamics and gene expression. It is involved in cell cycle progression, DNA repair, and transcriptional regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered expression of ANP32E may disrupt chromatin remodeling and gene expression, contributing to oncogenesis. | COSMIC; NCBI Gene |
| Neurodevelopmental disorders | Potential role due to involvement in chromatin regulation, though direct evidence is limited. | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 45.2 | High |
| Brain | 12.8 | Medium |
| Lung | 8.5 | Medium |
| Liver | 3.1 | Low |
| Heart | 2.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 25.0 | High expression |
| HeLa | 18.5 | Moderate expression |
| K562 | 10.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T (p.Arg41Cys) | Missense | <0.01% | Unknown functional impact |
| c.456G>A (p.Val152Met) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; no confirmed loss-of-function mutations reported.
Gain of Function (GOF)
Not well characterized; no confirmed gain-of-function mutations reported.
Dominant Negative (DN)
Not well characterized; no confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • histone chaperone activity | • nucleosome assembly |
| • chromatin remodeling | • protein binding |
| • nucleus |
Pathways
• Chromatin organization
• Nucleosome assembly
Protein Summary
ANP32E is a 268-amino acid protein that belongs to the acidic nuclear phosphoprotein 32 family. It contains an N-terminal leucine-rich repeat domain and a C-terminal acidic region. The protein acts as a histone chaperone, specifically removing H2A.Z/H2B dimers from nucleosomes, thereby regulating chromatin structure and gene expression. It is ubiquitously expressed with highest levels in testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ANP32E Knockout HEK293 Cell Line | EDJ-KQ9726 | Human | 81611 | Details Get a Quote |
| ANP32E Knockout A-549 Cell Line | EDJ-KQ36544 | Human | 81611 | Details Get a Quote |
| ANP32E Knockout HCT 116 Cell Line | EDJ-KQ36545 | Human | 81611 | Details Get a Quote |
| ANP32E Knockout HeLa Cell Line | EDJ-KQ36546 | Human | 81611 | Details Get a Quote |
