ANP32D
Acidic Nuclear Phosphoprotein 32 Family Member D
Gene Information Card
| Symbol | ANP32D |
|---|---|
| Full Name | Acidic Nuclear Phosphoprotein 32 Family Member D |
| Gene Type | Protein coding |
| Chromosomal Location | 12q13.12 |
| NCBI Gene ID | 23519 ncbi.nlm.nih.gov/gene/23519 |
| Ensembl ID | ENSG00000135446 |
| UniProt ID | O43474 |
| OMIM ID | 606830 |
| HGNC ID | 16673 |
| Aliases | PP32R2, LANP-L, PHAP1L |
Description
ANP32D (Acidic Nuclear Phosphoprotein 32 Family Member D) is a protein-coding gene located on chromosome 12q13.12. It encodes a member of the acidic nuclear phosphoprotein 32 family, which is involved in chromatin remodeling, regulation of protein phosphatase 2A (PP2A), and modulation of cell growth and apoptosis. ANP32D is expressed in various tissues and has been implicated in cancer biology.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Altered expression may affect PP2A activity and cell cycle regulation | COSMIC, NCBI Gene |
| Lung cancer | Overexpression observed in tumor samples; potential role in tumorigenesis | COSMIC |
| Breast cancer | Differential expression linked to prognosis | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 8.2 | Low |
| Bone marrow | 6.0 | Low |
| Brain | 3.1 | Low |
| Liver | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.0 | Moderate expression |
| HeLa | 10.2 | Low expression |
| A549 | 8.5 | Low expression |
| MCF7 | 7.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | Rare | Unknown functional impact |
| c.100C>T | Nonsense | Rare | Potential loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations may lead to truncated protein and loss of function.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • nucleus (GO:0005634) |
| • cytoplasm (GO:0005737) | • protein phosphatase regulator activity (GO:0019888) |
Pathways
• PP2A signaling
• Chromatin remodeling
Protein Summary
ANP32D encodes a 237-amino acid protein (UniProt O43474) belonging to the acidic nuclear phosphoprotein 32 family. It contains an N-terminal leucine-rich repeat domain and a C-terminal acidic region. The protein interacts with protein phosphatase 2A (PP2A) and may regulate its activity, influencing cell proliferation and apoptosis. ANP32D is localized in the nucleus and cytoplasm.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ANP32D Knockout HEK293 Cell Line | EDJ-KQ8050 | Human | 23519 | Details Get a Quote |
| ANP32D Knockout HeLa Cell Line | EDJ-KQ55756 | Human | 23519 | Details Get a Quote |
| ANP32D Knockout A-549 Cell Line | EDJ-KQ64254 | Human | 23519 | Details Get a Quote |
| ANP32D Knockout HCT 116 Cell Line | EDJ-KQ72700 | Human | 23519 | Details Get a Quote |
