ANKRD66
Ankyrin Repeat Domain 66
Gene Information Card
| Symbol | ANKRD66 |
|---|---|
| Full Name | Ankyrin Repeat Domain 66 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q21.3 |
| NCBI Gene ID | 100131755 ncbi.nlm.nih.gov/gene/100131755 |
| Ensembl ID | ENSG00000204149 |
| UniProt ID | A6NKD2 |
| OMIM ID | - |
| HGNC ID | 37291 |
| Aliases | FLJ46365, MGC16384 |
Description
ANKRD66 (Ankyrin Repeat Domain 66) is a protein-coding gene located on chromosome 1q21.3. The encoded protein contains ankyrin repeats, which are common motifs involved in protein-protein interactions. The function of ANKRD66 is not fully characterized, but it is predicted to play a role in cellular signaling or structural organization. Expression data suggest low to moderate levels in certain tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations | Not established | No evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 2.1 | Low |
| Brain | 1.5 | Low |
| Lung | 0.8 | Not detected |
| Liver | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.3 | Low expression |
| K562 | 0.1 | Not detected |
| HeLa | 0.2 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported mutations | - | - | - |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Protein Summary
ANKRD66 is a small protein (approximately 200 amino acids) containing ankyrin repeats. Its precise biological function remains unknown, but ankyrin repeats typically mediate protein-protein interactions. No functional studies or structural data are currently available.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ANKRD66 Knockout HEK293 Cell Line | EDJ-KQ12379 | Human | 100287718 | Details Get a Quote |
| ANKRD66 Knockout HeLa Cell Line | EDJ-KQ60868 | Human | 100287718 | Details Get a Quote |
| ANKRD66 Knockout A-549 Cell Line | EDJ-KQ69342 | Human | 100287718 | Details Get a Quote |
| ANKRD66 Knockout HCT 116 Cell Line | EDJ-KQ77696 | Human | 100287718 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
