ANKRD65
Ankyrin Repeat Domain 65
Gene Information Card
| Symbol | ANKRD65 |
|---|---|
| Full Name | Ankyrin Repeat Domain 65 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.33 |
| NCBI Gene ID | 441869 ncbi.nlm.nih.gov/gene/441869 |
| Ensembl ID | ENSG00000269335 |
| UniProt ID | Q6ZP65 |
| OMIM ID | 617913 |
| HGNC ID | 37279 |
| Aliases | ANKRD65, FLJ46361 |
Description
ANKRD65 (ankyrin repeat domain 65) is a protein-coding gene located on chromosome 1p36.33. It encodes a protein containing ankyrin repeats, which are common motifs involved in protein-protein interactions. The gene is expressed in various tissues and may play roles in cellular signaling and structural organization.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Brain | 3.1 | Low |
| Lung | 2.8 | Low |
| Heart | 2.5 | Low |
| Liver | 1.9 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 4.5 | Low expression |
| HeLa | 3.8 | Low expression |
| K562 | 2.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Protein Summary
The ANKRD65 protein contains ankyrin repeat domains, which are typically involved in mediating protein-protein interactions. Its specific biological function remains largely uncharacterized, but it may participate in cellular signaling or structural complexes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ANKRD65 Knockout HEK293 Cell Line | EDJ-KQ12378 | Human | 441869 | Details Get a Quote |
| ANKRD65 Knockout HeLa Cell Line | EDJ-KQ60440 | Human | 441869 | Details Get a Quote |
| ANKRD65 Knockout A-549 Cell Line | EDJ-KQ68908 | Human | 441869 | Details Get a Quote |
| ANKRD65 Knockout HCT 116 Cell Line | EDJ-KQ77269 | Human | 441869 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
