ANKRD16
Ankyrin Repeat Domain 16
Gene Information Card
| Symbol | ANKRD16 |
|---|---|
| Full Name | Ankyrin Repeat Domain 16 |
| Gene Type | Protein coding |
| Chromosomal Location | 10p15.1 |
| NCBI Gene ID | 54547 ncbi.nlm.nih.gov/gene/54547 |
| Ensembl ID | ENSG00000165801 |
| UniProt ID | Q6ZP29 |
| OMIM ID | 615355 |
| HGNC ID | 28310 |
| Aliases | FLJ12606, MGC131851 |
Description
ANKRD16 (ankyrin repeat domain 16) is a protein-coding gene located on chromosome 10p15.1. It encodes a protein containing ankyrin repeats, which are common motifs involved in protein-protein interactions. The exact biological function of ANKRD16 is not fully characterized, but it is thought to play a role in cellular signaling or structural organization. Expression data indicate low to moderate levels in various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 3.2 | Low |
| Brain | 2.1 | Low |
| Lung | 1.5 | Low |
| Liver | 0.8 | Not detected |
| Kidney | 1.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 2.5 | Low expression |
| HeLa | 1.8 | Low expression |
| K562 | 1.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants | Not available | Not available | Not available |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • GO:0005515 (protein binding) | • GO:0005737 (cytoplasm) |
Pathways
• No curated pathways
Protein Summary
The ANKRD16 protein (UniProt Q6ZP29) contains ankyrin repeat domains, which typically mediate protein-protein interactions. Its precise molecular function remains unclear, but it is predicted to localize to the cytoplasm. No disease-associated mutations or functional studies have been reported in major databases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ANKRD16 Knockout HEK293 Cell Line | EDJ-KQ11451 | Human | 54522 | Details Get a Quote |
| ANKRD16 Knockout A-549 Cell Line | EDJ-KQ39733 | Human | 54522 | Details Get a Quote |
| ANKRD16 Knockout HCT 116 Cell Line | EDJ-KQ39734 | Human | 54522 | Details Get a Quote |
| ANKRD16 Knockout HeLa Cell Line | EDJ-KQ39735 | Human | 54522 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
