ANGPT4 (Angiopoietin 4)
Key regulator of angiogenesis and vascular permeability
Gene Information Card
| Symbol | ANGPT4 |
|---|---|
| Full Name | Angiopoietin 4 |
| Gene Type | Protein coding |
| Chromosomal Location | 20p13 |
| NCBI Gene ID | 51378 ncbi.nlm.nih.gov/gene/51378 |
| Ensembl ID | ENSG00000101276 |
| UniProt ID | Q9Y264 |
| OMIM ID | 603705 |
| HGNC ID | 486 |
| Aliases | ANG-4, ANG4, angiopoietin-4 |
Description
ANGPT4 encodes angiopoietin 4, a member of the angiopoietin family of vascular growth factors. It acts as a ligand for the TEK/TIE2 receptor tyrosine kinase, modulating angiogenesis, vascular permeability, and endothelial cell survival. ANGPT4 is primarily expressed in the lung and placenta and plays a role in both physiological and pathological vascular remodeling.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Diabetic Retinopathy | ANGPT4 overexpression contributes to retinal neovascularization via TIE2 signaling | PMID: 23592976 |
| Cancer (various) | ANGPT4 promotes tumor angiogenesis and metastasis in breast and lung cancers | PMID: 25624455 |
| Lymphedema | Mutations in ANGPT4 impair lymphatic vessel development | PMID: 31548638 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Placenta | 8.3 | Medium |
| Heart | 2.1 | Low |
| Liver | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HUVEC | 15.2 | Endothelial cell line |
| A549 | 3.8 | Lung carcinoma |
| MCF7 | 1.2 | Breast cancer |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.442G>A (p.Gly148Arg) | Missense | <0.01% | Reduced TIE2 binding affinity |
| c.1003C>T (p.Arg335Trp) | Missense | 0.02% | Impaired secretion |
Mutation functional classification
Loss of Function (LOF)
p.Gly148Arg reduces receptor activation
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • GO:0001525 (angiogenesis) | • GO:0005515 (protein binding) |
| • GO:0008083 (growth factor activity) | • GO:0048010 (vascular endothelial growth factor receptor signaling pathway) |
Pathways
• Angiopoietin-TIE signaling pathway (Reactome: R-HSA-210990)
• VEGF-VEGFR signaling (KEGG: hsa04370)
Protein Summary
Angiopoietin 4 is a secreted glycoprotein of 503 amino acids (precursor) that forms homodimers. It contains a coiled-coil domain and a fibrinogen-like domain, essential for TIE2 receptor binding. The protein promotes endothelial cell migration and tube formation in vitro and is implicated in tumor angiogenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ANGPT4 Knockout HEK293 Cell Line | EDJ-KQ606 | Human | 51378 | Details Get a Quote |
| ANGPT4 Knockout HeLa Cell Line | EDJ-KQ56303 | Human | 51378 | Details Get a Quote |
| ANGPT4 Knockout A-549 Cell Line | EDJ-KQ64792 | Human | 51378 | Details Get a Quote |
| ANGPT4 Knockout HCT 116 Cell Line | EDJ-KQ73238 | Human | 51378 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
