ANAPC16
Anaphase Promoting Complex Subunit 16
Gene Information Card
| Symbol | ANAPC16 |
|---|---|
| Full Name | Anaphase Promoting Complex Subunit 16 |
| Gene Type | Protein coding |
| Chromosomal Location | 10q22.1 |
| NCBI Gene ID | 119504 ncbi.nlm.nih.gov/gene/119504 |
| Ensembl ID | ENSG00000166295 |
| UniProt ID | Q96DE5 |
| OMIM ID | 614486 |
| HGNC ID | 25861 |
| Aliases | APC16, C10orf104, HSPC051 |
Description
ANAPC16 encodes a subunit of the anaphase-promoting complex/cyclosome (APC/C), a ubiquitin ligase that regulates cell cycle progression by targeting specific proteins for degradation. This subunit is essential for complex assembly and activity.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Altered APC/C activity may contribute to chromosomal instability | COSMIC |
| Breast cancer | Dysregulation of APC/C subunits linked to tumorigenesis | COSMIC |
| Endometrial cancer | Mutations in APC/C components observed | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 10.2 | Medium |
| Brain | 8.1 | Low |
| Liver | 6.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.0 | High expression |
| HeLa | 12.5 | Moderate expression |
| K562 | 9.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287G>A (p.Arg96Gln) | Missense | <0.01% | Unknown functional impact |
| c.412_413insA | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations likely disrupt APC/C assembly and activity.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • ubiquitin ligase complex | • anaphase-promoting complex |
| • cell cycle | • protein ubiquitination |
Pathways
• Cell cycle
• APC/C-mediated degradation of cyclin B
• Ubiquitin mediated proteolysis
Protein Summary
ANAPC16 is a 12 kDa protein that forms part of the APC/C complex. It is involved in substrate recognition and complex stability, playing a critical role in mitotic exit and G1 phase maintenance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ANAPC16 Knockout HEK293 Cell Line | EDJ-KQ7640 | Human | 119504 | Details Get a Quote |
| ANAPC16 Knockout A-549 Cell Line | EDJ-KQ33000 | Human | 119504 | Details Get a Quote |
| ANAPC16 Knockout HCT 116 Cell Line | EDJ-KQ33001 | Human | 119504 | Details Get a Quote |
| ANAPC16 Knockout HeLa Cell Line | EDJ-KQ33002 | Human | 119504 | Details Get a Quote |
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