ANAPC13
Anaphase Promoting Complex Subunit 13
Gene Information Card
| Symbol | ANAPC13 |
|---|---|
| Full Name | Anaphase Promoting Complex Subunit 13 |
| Gene Type | Protein coding |
| Chromosomal Location | 3q22.1 |
| NCBI Gene ID | 25847 ncbi.nlm.nih.gov/gene/25847 |
| Ensembl ID | ENSG00000163872 |
| UniProt ID | Q9BSJ8 |
| OMIM ID | 614745 |
| HGNC ID | 15732 |
| Aliases | APC13, SWM1 |
Description
ANAPC13 encodes a subunit of the anaphase-promoting complex/cyclosome (APC/C), a ubiquitin ligase that regulates cell cycle progression by targeting specific proteins for degradation. The subunit is essential for APC/C assembly and activity, particularly during mitosis and G1 phase.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Altered APC/C activity may disrupt cell cycle control; ANAPC13 expression changes observed in tumor tissues | COSMIC; NCBI Gene |
| Breast cancer | Dysregulation of APC/C subunits including ANAPC13 linked to genomic instability | COSMIC; NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Lymph node | 9.8 | Medium |
| Brain | 6.5 | Low |
| Liver | 5.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 10.1 | Cervical cancer cell line |
| HEK 293 | 8.7 | Embryonic kidney cell line |
| K562 | 7.4 | Leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287A>G (p.Asn96Ser) | Missense | <0.1% | Unknown significance; reported in COSMIC |
| c.112C>T (p.Arg38Trp) | Missense | <0.1% | Unknown significance; reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • ubiquitin protein ligase activity | • anaphase-promoting complex |
| • cell cycle | • protein ubiquitination |
| • mitotic cell cycle |
Pathways
• Cell Cycle (KEGG hsa04110)
• Ubiquitin mediated proteolysis (KEGG hsa04120)
Protein Summary
ANAPC13 is a small subunit (approximately 8 kDa) of the APC/C complex. It contains a conserved domain that stabilizes the complex and is required for substrate recognition and ubiquitination. The protein is localized in the nucleus and cytoplasm, with peak expression during mitosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ANAPC13 Knockout HEK293 Cell Line | EDJ-KQ8262 | Human | 25847 | Details Get a Quote |
| ANAPC13 Knockout A-549 Cell Line | EDJ-KQ34198 | Human | 25847 | Details Get a Quote |
| ANAPC13 Knockout HCT 116 Cell Line | EDJ-KQ34199 | Human | 25847 | Details Get a Quote |
| ANAPC13 Knockout HeLa Cell Line | EDJ-KQ34200 | Human | 25847 | Details Get a Quote |
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