ANAPC10
Anaphase Promoting Complex Subunit 10
Gene Information Card
| Symbol | ANAPC10 |
|---|---|
| Full Name | Anaphase Promoting Complex Subunit 10 |
| Gene Type | protein-coding |
| Chromosomal Location | 4q31.21 |
| NCBI Gene ID | 10393 ncbi.nlm.nih.gov/gene/10393 |
| Ensembl ID | ENSG00000164124 |
| UniProt ID | Q9UM13 |
| OMIM ID | 609745 |
| HGNC ID | 24012 |
| Aliases | APC10, DOC1, MGC12685 |
Description
ANAPC10 encodes a subunit of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The protein is essential for substrate recognition and ubiquitination of securin and cyclins.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Altered APC/C activity may contribute to chromosomal instability | COSMIC; PMID: 12080066 |
| Endometrial cancer | Somatic mutations in ANAPC10 reported | COSMIC; PMID: 23525077 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 9.8 | Medium |
| Brain | 6.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 10.1 | Cervical cancer cell line |
| HEK 293 | 8.5 | Embryonic kidney cell line |
| K562 | 7.3 | Leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287A>G (p.Asn96Ser) | Missense | <0.01% | Unknown functional impact |
| c.412C>T (p.Arg138Trp) | Missense | <0.01% | Reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; predicted to impair APC/C activity
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • ubiquitin protein ligase activity | • anaphase-promoting complex |
| • cell cycle | • protein ubiquitination |
| • mitotic cell cycle |
Pathways
• Cell Cycle
• Mitotic
• APC/C-mediated degradation of cell cycle proteins
• Ubiquitin mediated proteolysis
Protein Summary
ANAPC10 is a 185-amino acid protein that forms part of the APC/C complex. It contains a DOC domain critical for substrate binding and ubiquitin chain elongation. The protein is highly conserved across eukaryotes.
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