ALPG (Alkaline Phosphatase, Germ Cell)
Gene encoding the germ cell-specific alkaline phosphatase isozyme
Gene Information Card
| Symbol | ALPG |
|---|---|
| Full Name | Alkaline Phosphatase, Germ Cell |
| Gene Type | protein-coding |
| Chromosomal Location | 2q37.1 |
| NCBI Gene ID | 251 ncbi.nlm.nih.gov/gene/251 |
| Ensembl ID | ENSG00000163286 |
| UniProt ID | P10696 |
| OMIM ID | 171810 |
| HGNC ID | 438 |
| Aliases | GCAP, ALP-1, PLAP-like, ALPG |
Description
ALPG (alkaline phosphatase, germ cell) is a protein-coding gene located on chromosome 2q37.1. It encodes a member of the alkaline phosphatase family, specifically the germ cell-specific isozyme. This enzyme is a membrane-bound glycoprotein that hydrolyzes phosphate esters at alkaline pH. ALPG is primarily expressed in germ cells of the testis and in the thymus, and its expression is also observed in certain cancers, making it a potential biomarker.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Germ cell tumors | Elevated ALPG expression in seminomas and other germ cell neoplasms | PubMed, NCBI Gene |
| Testicular cancer | ALPG is a serum marker for testicular germ cell tumors | PubMed, NCBI Gene |
| Placental-like alkaline phosphatase elevation in cancer | Ectopic expression in various malignancies (e.g., ovarian, lung) | PubMed, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.8 | Low |
| Thymus | 0.3 | Low |
| Placenta | 0.1 | Not detected |
| Ovary | 0.0 | Not detected |
| Lung | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| NTERA-2 (embryonal carcinoma) | 2.5 | Moderate expression |
| HeLa (cervical carcinoma) | 0.1 | Low/not detected |
| A549 (lung carcinoma) | 0.0 | Not detected |
| MCF7 (breast carcinoma) | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.346G>A (p.Gly116Arg) | Missense | <0.01% | Unknown functional effect |
| c.793C>T (p.Arg265Trp) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ALPG.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • GO:0004035 - alkaline phosphatase activity | • GO:0016791 - phosphatase activity |
| • GO:0008152 - metabolic process | • GO:0005886 - plasma membrane |
| • GO:0016021 - integral component of membrane |
Pathways
• Phosphate metabolism
• GPI-anchor biosynthesis (indirect)
Protein Summary
The ALPG protein (UniProt P10696) is a 532-amino acid membrane-bound glycoprotein that functions as an alkaline phosphatase. It is anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor. The enzyme catalyzes the hydrolysis of phosphate esters at alkaline pH, playing a role in phosphate metabolism. Its expression is largely restricted to germ cells in the testis and thymus, and it is often re-expressed in germ cell tumors, serving as a clinical biomarker.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ALPG Knockout HEK293 Cell Line | EDJ-KQ4048 | Human | 251 | Details Get a Quote |
| ALPG Knockout HeLa Cell Line | EDJ-KQ52601 | Human | 251 | Details Get a Quote |
| ALPG Knockout A-549 Cell Line | EDJ-KQ61081 | Human | 251 | Details Get a Quote |
| ALPG Knockout HCT 116 Cell Line | EDJ-KQ69563 | Human | 251 | Details Get a Quote |
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