ALKAL2
ALK and LTK Ligand 2
Gene Information Card
| Symbol | ALKAL2 |
|---|---|
| Full Name | ALK and LTK ligand 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 2p23.2 |
| NCBI Gene ID | 100506334 ncbi.nlm.nih.gov/gene/100506334 |
| Ensembl ID | ENSG00000214595 |
| UniProt ID | Q6UX46 |
| OMIM ID | 617008 |
| HGNC ID | 44002 |
| Aliases | FAM150B, ALKAL2, AUG-alpha, AUG-β |
Description
ALKAL2 (ALK and LTK ligand 2) is a protein-coding gene located on chromosome 2p23.2. It encodes a ligand for the receptor tyrosine kinases ALK and LTK, playing a role in neuronal development and cancer. The protein is secreted and activates ALK/LTK signaling pathways.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Neuroblastoma | ALKAL2 overexpression activates ALK signaling, promoting tumor growth | PMID: 25775507 |
| Lung adenocarcinoma | ALKAL2 fusion with ALK leads to constitutive activation | PMID: 31570887 |
| Inflammatory myofibroblastic tumor | ALKAL2-ALK fusions drive oncogenic signaling | PMID: 31570887 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 0.0 | Not detected |
| Testis | 0.0 | Not detected |
| Adipose tissue | 0.0 | Not detected |
| Lung | 0.0 | Not detected |
| Liver | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.0 | Not detected |
| HeLa | 0.0 | Not detected |
| K562 | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown |
| c.100C>T | missense | <0.1% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
ALKAL2-ALK fusions result in gain-of-function via constitutive ALK activation.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • receptor tyrosine kinase ligand | • extracellular region |
| • signal transduction | • cell surface receptor signaling pathway |
Pathways
• ALK signaling
• LTK signaling
Protein Summary
ALKAL2 is a secreted ligand that binds to and activates the receptor tyrosine kinases ALK and LTK. It is involved in neuronal development and has been implicated in oncogenic fusions with ALK in various cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ALKAL2 Knockout HEK293 Cell Line | EDJ-KQ12334 | Human | 285016 | Details Get a Quote |
| ALKAL2 Knockout HeLa Cell Line | EDJ-KQ59496 | Human | 285016 | Details Get a Quote |
| ALKAL2 Knockout A-549 Cell Line | EDJ-KQ67963 | Human | 285016 | Details Get a Quote |
| ALKAL2 Knockout HCT 116 Cell Line | EDJ-KQ76340 | Human | 285016 | Details Get a Quote |
