AGTRAP (Angiotensin II Receptor Associated Protein)
A regulator of angiotensin II receptor trafficking and signaling
Gene Information Card
| Symbol | AGTRAP |
|---|---|
| Full Name | Angiotensin II Receptor Associated Protein |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.22 |
| NCBI Gene ID | 57085 ncbi.nlm.nih.gov/gene/57085 |
| Ensembl ID | ENSG00000177674 |
| UniProt ID | Q6RW13 |
| OMIM ID | 606172 |
| HGNC ID | 13590 |
| Aliases | ATRAP, FLJ20054 |
Description
AGTRAP (angiotensin II receptor associated protein) encodes a transmembrane protein that interacts with the angiotensin II type 1 receptor (AT1R). It modulates AT1R internalization, desensitization, and signaling, playing a role in blood pressure regulation and cardiovascular homeostasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hypertension | AGTRAP modulates AT1R internalization; altered expression may affect blood pressure regulation | PMID: 15689449 |
| Cardiovascular disease | Dysregulation of AGTRAP influences AT1R signaling, contributing to vascular remodeling | PMID: 19667188 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 5.2 | Low |
| Kidney | 8.1 | Medium |
| Liver | 3.4 | Low |
| Brain | 6.7 | Medium |
| Lung | 4.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 7.3 | High expression in transfected cells |
| HUVEC | 5.8 | Endothelial expression |
| HepG2 | 4.1 | Hepatocellular expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200C>T | missense | <0.01% | p.Thr67Ile; potential effect on protein stability |
| c.347G>A | missense | <0.01% | p.Arg116His; reported in ClinVar |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants may impair AT1R binding or internalization.
Gain of Function (GOF)
Not established.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • GO:0031625 (ubiquitin protein ligase binding) | • GO:0038023 (signaling receptor activity) |
| • GO:0005886 (plasma membrane) | • GO:0006897 (endocytosis) |
| • GO:0007165 (signal transduction) |
Pathways
• Angiotensin II signaling via AT1 receptor
• GPCR internalization and desensitization
Protein Summary
AGTRAP is a 159-amino acid transmembrane protein that localizes to the plasma membrane and endosomes. It binds the C-terminal tail of the angiotensin II type 1 receptor (AT1R), promoting receptor internalization and attenuating signaling. This regulatory function is critical for controlling vasoconstriction, fluid balance, and blood pressure.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| AGTRAP Knockout HEK293 Cell Line | EDJ-KQ12314 | Human | 57085 | Details Get a Quote |
| AGTRAP Knockout A-549 Cell Line | EDJ-KQ41149 | Human | 57085 | Details Get a Quote |
| AGTRAP Knockout HCT 116 Cell Line | EDJ-KQ41150 | Human | 57085 | Details Get a Quote |
| AGTRAP Knockout HeLa Cell Line | EDJ-KQ39896 | Human | 57085 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
