AGT (Angiotensinogen) Gene
Key regulator of blood pressure and electrolyte homeostasis
Gene Information Card
| Symbol | AGT |
|---|---|
| Full Name | Angiotensinogen |
| Gene Type | protein-coding |
| Chromosomal Location | 1q42.2 |
| NCBI Gene ID | 183 ncbi.nlm.nih.gov/gene/183 |
| Ensembl ID | ENSG00000135744 |
| UniProt ID | P01019 |
| OMIM ID | 106150 |
| HGNC ID | 333 |
| Aliases | SERPINA8, ANHU, hFLT1 |
Description
The AGT gene encodes angiotensinogen, a precursor protein of the renin-angiotensin system (RAS). It is cleaved by renin to produce angiotensin I, which is further converted to angiotensin II, a potent vasoconstrictor that regulates blood pressure, fluid balance, and electrolyte homeostasis. AGT is primarily expressed in the liver and is involved in cardiovascular and renal physiology.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hypertension | Increased AGT expression or mutations lead to elevated angiotensin II, causing vasoconstriction and increased blood pressure. | ClinVar, OMIM |
| Preeclampsia | AGT variants contribute to placental ischemia and maternal hypertension during pregnancy. | OMIM, NCBI |
| Renal tubular dysgenesis | Loss-of-function mutations in AGT impair renal development, leading to neonatal renal failure. | OMIM, ClinVar |
| Chronic kidney disease | AGT polymorphisms are associated with progression of renal fibrosis and hypertension. | NCBI, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | High |
| Kidney | 3.2 | Medium |
| Heart | 1.8 | Low |
| Brain | 0.9 | Low |
| Lung | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.0 | Hepatocyte cell line |
| HEK293 | 2.1 | Embryonic kidney cells |
| HUVEC | 0.3 | Endothelial cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.857C>T (p.Thr286Met) | Missense | 0.5% | Associated with hypertension |
| c.1072G>A (p.Val358Ile) | Missense | 0.2% | Reduced angiotensinogen secretion |
| c.1A>G (p.Met1Val) | Start loss | <0.1% | Loss of function, renal tubular dysgenesis |
Mutation functional classification
Loss of Function (LOF)
Mutations such as p.Met1Val cause complete loss of angiotensinogen production, leading to renal tubular dysgenesis.
Gain of Function (GOF)
Missense variants like p.Thr286Met increase angiotensin II production, contributing to hypertension.
Dominant Negative (DN)
No dominant-negative mutations reported for AGT.
View complete mutation data：
Gene Ontology (GO)
| • GO:0002003 – angiotensin maturation | • GO:0005576 – extracellular region |
| • GO:0005615 – extracellular space | • GO:0008233 – peptidase activity |
| • GO:0010466 – negative regulation of peptidase activity |
Pathways
• Renin-angiotensin system (RAS)
• Regulation of blood pressure
• Aldosterone synthesis and secretion
Protein Summary
Angiotensinogen is a 485-amino acid glycoprotein primarily synthesized in the liver. It is the sole substrate for renin, initiating the RAS cascade. The protein contains a serpin domain but lacks inhibitory activity. Its cleavage by renin yields angiotensin I, which is further processed to angiotensin II, a key hormone in cardiovascular and renal regulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| AGTR1 Knockout HEK293 Cell Line | EDJ-KQ1464 | Human | 185 | Details Get a Quote |
| AGT Knockout HEK293 Cell Line | EDJ-KQ1715 | Human | 183 | Details Get a Quote |
| AGTR2 Knockout HEK293 Cell Line | EDJ-KQ4028 | Human | 186 | Details Get a Quote |
| AGTPBP1 Knockout HEK293 Cell Line | EDJ-KQ7265 | Human | 23287 | Details Get a Quote |
| MAGT1 Knockout HEK293 Cell Line | EDJ-KQ9959 | Human | 84061 | Details Get a Quote |
| AGTRAP Knockout HEK293 Cell Line | EDJ-KQ12314 | Human | 57085 | Details Get a Quote |
| AGTR1 Knockout A-549 Cell Line | EDJ-KQ21029 | Human | 185 | Details Get a Quote |
| AGTRAP Knockout A-549 Cell Line | EDJ-KQ41149 | Human | 57085 | Details Get a Quote |
| AGTRAP Knockout HCT 116 Cell Line | EDJ-KQ41150 | Human | 57085 | Details Get a Quote |
| AGT Knockout HeLa Cell Line | EDJ-KQ21553 | Human | 183 | Details Get a Quote |
| AGTPBP1 Knockout A-549 Cell Line | EDJ-KQ33611 | Human | 23287 | Details Get a Quote |
| AGTPBP1 Knockout HCT 116 Cell Line | EDJ-KQ33612 | Human | 23287 | Details Get a Quote |
| AGTPBP1 Knockout HeLa Cell Line | EDJ-KQ33613 | Human | 23287 | Details Get a Quote |
| MAGT1 Knockout HCT 116 Cell Line | EDJ-KQ35684 | Human | 84061 | Details Get a Quote |
| MAGT1 Knockout A-549 Cell Line | EDJ-KQ36878 | Human | 84061 | Details Get a Quote |
Displaying Records 1 To 15 Of 24 Records
