AGR3 (Anterior Gradient 3)
Protein disulfide isomerase family member with roles in mucin production and cancer
Gene Information Card
| Symbol | AGR3 |
|---|---|
| Full Name | Anterior Gradient 3, Protein Disulfide Isomerase Family Member |
| Gene Type | protein-coding |
| Chromosomal Location | 7p21.3 |
| NCBI Gene ID | 155465 ncbi.nlm.nih.gov/gene/155465 |
| Ensembl ID | ENSG00000146540 |
| UniProt ID | Q8TD06 |
| OMIM ID | 609482 |
| HGNC ID | 24020 |
| Aliases | HAG-3, PDIA18, AG-3, AGR3 |
Description
AGR3 encodes a member of the protein disulfide isomerase (PDI) family, localized to the endoplasmic reticulum. It is involved in oxidative protein folding and is highly expressed in mucin-secreting epithelial cells. AGR3 is upregulated in several cancers, including breast and ovarian, and may serve as a biomarker for tumor progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of AGR3 in estrogen receptor-positive tumors; may promote cell survival and chemoresistance | PMID: 21947068 |
| Ovarian cancer | Elevated AGR3 expression in serous ovarian carcinoma; associated with poor prognosis | PMID: 23104868 |
| Mucinous adenocarcinoma | AGR3 is a marker of mucinous differentiation in various tissues | PMID: 19074856 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Trachea | 45.2 | High |
| Salivary gland | 38.1 | High |
| Stomach | 25.6 | Medium |
| Lung | 18.4 | Medium |
| Breast | 12.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 28.5 | Estrogen receptor-positive line |
| OVCAR3 (ovarian cancer) | 22.1 | Serous carcinoma line |
| A549 (lung cancer) | 8.7 | Low expression |
| HeLa (cervical cancer) | 5.2 | Very low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.293C>T (p.Ala98Val) | Missense | <0.1% | Unknown significance |
| c.412G>A (p.Gly138Ser) | Missense | <0.1% | Unknown significance |
| c.523_524insA | Frameshift | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.523_524insA) are predicted to cause premature truncation and loss of PDI activity.
Gain of Function (GOF)
No gain-of-function mutations have been reported for AGR3.
Dominant Negative (DN)
No dominant-negative mutations have been characterized.
View complete mutation data：
Gene Ontology (GO)
| • protein disulfide isomerase activity | • endoplasmic reticulum lumen |
| • protein folding | • response to endoplasmic reticulum stress |
| • cell adhesion |
Pathways
• Protein processing in endoplasmic reticulum
• Unfolded protein response
Protein Summary
AGR3 is a 166-amino acid protein with a thioredoxin-like domain characteristic of PDI family members. It catalyzes disulfide bond formation and rearrangement during protein folding. AGR3 is secreted and can be detected in serum, making it a potential biomarker for mucinous tumors.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| AGR3 Knockout HEK293 Cell Line | EDJ-KQ12313 | Human | 155465 | Details Get a Quote |
| AGR3 Knockout HeLa Cell Line | EDJ-KQ58757 | Human | 155465 | Details Get a Quote |
| AGR3 Knockout A-549 Cell Line | EDJ-KQ67241 | Human | 155465 | Details Get a Quote |
| AGR3 Knockout HCT 116 Cell Line | EDJ-KQ75638 | Human | 155465 | Details Get a Quote |
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