ADRM1: Adhesion Regulating Molecule 1
A key component of the deubiquitinating enzyme complex with roles in proteostasis and cancer
Gene Information Card
| Symbol | ADRM1 |
|---|---|
| Full Name | Adhesion Regulating Molecule 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 20q13.33 |
| NCBI Gene ID | 11047 ncbi.nlm.nih.gov/gene/11047 |
| Ensembl ID | ENSG00000130706 |
| UniProt ID | Q16186 |
| OMIM ID | 610088 |
| HGNC ID | 1579 |
| Aliases | RPN13, GP110, hRpn13, ADRM1 |
Description
ADRM1 (Adhesion Regulating Molecule 1) encodes a component of the 26S proteasome, specifically the 19S regulatory particle subunit RPN13. It functions as a ubiquitin receptor and activates the deubiquitinating enzyme UCHL5. ADRM1 is involved in proteasomal degradation, cell adhesion, and signaling. Overexpression is observed in multiple cancers and correlates with poor prognosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (multiple types) | Overexpression of ADRM1 enhances proteasomal degradation of tumor suppressors and promotes cell proliferation | COSMIC, ClinVar |
| Ovarian cancer | ADRM1 amplification and overexpression linked to chemoresistance and poor survival | COSMIC, NCBI Gene |
| Colorectal cancer | ADRM1 upregulation associated with metastasis and reduced patient survival | COSMIC, NCBI Gene |
| Hepatocellular carcinoma | ADRM1 overexpression promotes tumor growth via NF-κB pathway activation | NCBI Gene, UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adrenal gland | 13.2 | Medium |
| Bone marrow | 8.5 | Low |
| Brain | 6.1 | Low |
| Colon | 15.8 | Medium |
| Kidney | 12.4 | Medium |
| Liver | 11.9 | Medium |
| Lung | 14.3 | Medium |
| Ovary | 16.7 | Medium |
| Pancreas | 10.2 | Medium |
| Prostate | 13.6 | Medium |
| Skin | 9.8 | Low |
| Spleen | 7.3 | Low |
| Testis | 18.5 | High |
| Thyroid | 11.1 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 22.4 | Cervical cancer cell line |
| A549 | 19.8 | Lung cancer cell line |
| MCF7 | 21.1 | Breast cancer cell line |
| HepG2 | 18.5 | Liver cancer cell line |
| K562 | 15.3 | Leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | 0.01% | Start codon loss, predicted loss of function |
| c.287C>T | Missense | 0.02% | p.Pro96Leu, uncertain significance |
| c.512A>G | Missense | 0.01% | p.Asn171Ser, uncertain significance |
| c.674G>A | Missense | 0.01% | p.Arg225Gln, uncertain significance |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants may impair proteasome binding or UCHL5 activation, but no confirmed loss-of-function mutations are well-characterized in human disease.
Gain of Function (GOF)
Gene amplification and overexpression in cancers suggest a gain-of-function role by enhancing proteasomal degradation of tumor suppressors.
Dominant Negative (DN)
No dominant-negative mutations have been reported for ADRM1.
View complete mutation data：
Gene Ontology (GO)
| • GO:0006511 - ubiquitin-dependent protein catabolic process | • GO:0008540 - proteasome regulatory particle |
| • base subcomplex | • GO:0031593 - polyubiquitin modification-dependent protein binding |
| • GO:0043130 - ubiquitin binding | • GO:0061572 - UCHL5 deubiquitinase activator activity |
| • GO:0005634 - nucleus | • GO:0005737 - cytoplasm |
Pathways
• Proteasome degradation (Reactome: R-HSA-983168)
• Antigen processing and presentation (KEGG: hsa04612)
• Ubiquitin-mediated proteolysis (KEGG: hsa04120)
Protein Summary
ADRM1 (RPN13) is a 407-amino acid protein that serves as a ubiquitin receptor within the 19S regulatory particle of the 26S proteasome. It directly binds ubiquitin chains and recruits the deubiquitinating enzyme UCHL5, facilitating substrate deubiquitination prior to degradation. The protein also localizes to the plasma membrane and may regulate cell adhesion. Overexpression in cancers promotes tumor progression and chemoresistance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ADRM1 Knockout HEK293 Cell Line | EDJ-KQ12298 | Human | 11047 | Details Get a Quote |
| ADRM1 Knockout HeLa Cell Line | EDJ-KQ18106 | Human | 11047 | Details Get a Quote |
| ADRM1 Knockout HCT 116 Cell Line | EDJ-KQ41112 | Human | 11047 | Details Get a Quote |
| ADRM1 Knockout A-549 Cell Line | EDJ-KQ64051 | Human | 11047 | Details Get a Quote |
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