ADRB3 Gene (Beta-3 Adrenergic Receptor)
Comprehensive genomic and functional analysis of ADRB3, a key regulator of lipolysis and thermogenesis.
Gene Information Card
| Symbol | ADRB3 |
|---|---|
| Full Name | Adrenoceptor Beta 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 8p11.23 |
| NCBI Gene ID | 155 ncbi.nlm.nih.gov/gene/155 |
| Ensembl ID | ENSG00000188796 |
| UniProt ID | P13945 |
| OMIM ID | 109691 |
| HGNC ID | 287 |
| Aliases | BETA3AR, beta3-adrenoreceptor |
Description
The ADRB3 gene encodes the beta-3 adrenergic receptor, a G-protein-coupled receptor primarily expressed in adipose tissue. It mediates catecholamine-induced lipolysis and thermogenesis, playing a critical role in energy homeostasis. Variants in ADRB3 have been associated with obesity, type 2 diabetes, and metabolic syndrome.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | ADRB3 variants (e.g., Trp64Arg) reduce receptor activity, impairing lipolysis and promoting fat accumulation. | ClinVar, PMID: 7901213 |
| Type 2 Diabetes | Impaired ADRB3 signaling contributes to insulin resistance and altered energy expenditure. | OMIM, PMID: 10480503 |
| Metabolic Syndrome | ADRB3 polymorphisms are linked to increased visceral adiposity and dyslipidemia. | NCBI Gene, PMID: 11344271 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose Tissue | 12.5 | Medium |
| Gallbladder | 8.3 | Medium |
| Urinary Bladder | 6.1 | Low |
| Prostate | 4.7 | Low |
| Small Intestine | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Adipocytes | 15.0 | Primary brown and white adipocytes |
| HEK293 | 0.5 | Low endogenous expression |
| HepG2 | 0.2 | Minimal expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| Trp64Arg (rs4994) | Missense | 5-10% in various populations | Reduced receptor activity; associated with obesity and insulin resistance |
| Arg64Arg | Homozygous missense | <1% | Severe impairment of lipolysis; increased obesity risk |
Mutation functional classification
Loss of Function (LOF)
Trp64Arg variant reduces cAMP signaling and lipolytic response, leading to decreased energy expenditure.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported in ADRB3.
Dominant Negative (DN)
Not described for ADRB3.
View complete mutation data：
Gene Ontology (GO)
| • G-protein coupled receptor activity | • beta-3 adrenergic receptor activity |
| • adenylate cyclase-activating adrenergic receptor signaling pathway | • lipolysis |
| • thermogenesis | • positive regulation of MAPK cascade |
Pathways
• Adrenergic signaling in cardiomyocytes
• cAMP signaling pathway
• Regulation of lipolysis in adipocytes
Protein Summary
The beta-3 adrenergic receptor (ADRB3) is a 408-amino acid transmembrane protein that couples to Gs alpha subunit, activating adenylate cyclase and increasing intracellular cAMP. It is predominantly expressed in brown and white adipose tissue, where it stimulates lipolysis and thermogenesis. ADRB3 is a therapeutic target for obesity and metabolic disorders.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ADRB3 Knockout HEK293 Cell Line | EDJ-KQ50106 | Human | 155 | Details Get a Quote |
| ADRB3 Knockout HeLa Cell Line | EDJ-KQ52571 | Human | 155 | Details Get a Quote |
| ADRB3 Knockout A-549 Cell Line | EDJ-KQ61049 | Human | 155 | Details Get a Quote |
| ADRB3 Knockout HCT 116 Cell Line | EDJ-KQ69529 | Human | 155 | Details Get a Quote |
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