ADRA1B: Alpha-1B Adrenergic Receptor
G protein-coupled receptor mediating catecholamine signaling in smooth muscle and CNS
Gene Information Card
| Symbol | ADRA1B |
|---|---|
| Full Name | Adrenoceptor Alpha 1B |
| Gene Type | protein-coding |
| Chromosomal Location | 5q33.3 |
| NCBI Gene ID | 147 ncbi.nlm.nih.gov/gene/147 |
| Ensembl ID | ENSG00000170214 |
| UniProt ID | P35368 |
| OMIM ID | 104220 |
| HGNC ID | 278 |
| Aliases | ADRA1, ALPHA1B, ADRA1L1 |
Description
The ADRA1B gene encodes the alpha-1B adrenergic receptor, a G protein-coupled receptor (GPCR) that mediates the effects of catecholamines such as norepinephrine and epinephrine. It is involved in smooth muscle contraction, cardiac inotropy, and central nervous system signaling. Activation of this receptor triggers phospholipase C and intracellular calcium mobilization.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hypertension | Increased vascular smooth muscle contraction via Gq/11 signaling | ClinVar, OMIM |
| Benign prostatic hyperplasia | Overexpression in prostate stroma leading to smooth muscle tone | NCBI Gene, PubMed |
| Pheochromocytoma | Adrenal medullary tumor with elevated catecholamines activating ADRA1B | COSMIC, ClinVar |
| Cardiac hypertrophy | Chronic adrenergic stimulation promotes pathological remodeling | OMIM, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 8.2 | Medium |
| Prostate | 12.5 | High |
| Heart | 6.1 | Medium |
| Brain (cerebellum) | 4.3 | Low |
| Smooth muscle (aorta) | 15.0 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.5 | Low endogenous expression |
| A7r5 (rat aortic smooth muscle) | 22.3 | High; model for vascular studies |
| LNCaP (prostate cancer) | 9.8 | Moderate; relevant to BPH |
| SH-SY5Y (neuroblastoma) | 3.1 | Low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.776C>T (p.Pro259Leu) | Missense | <0.01% | Reduced receptor activity; ClinVar |
| c.1003G>A (p.Gly335Ser) | Missense | <0.01% | Altered ligand binding; ClinVar |
| c.1246C>T (p.Arg416Cys) | Missense | <0.01% | Unknown significance; ClinVar |
Mutation functional classification
Loss of Function (LOF)
p.Pro259Leu reduces Gq coupling and calcium signaling
Gain of Function (GOF)
No confirmed gain-of-function variants reported
Dominant Negative (DN)
Not described for ADRA1B
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity (GO:0004930) | • alpha1-adrenergic receptor activity (GO:0004937) |
| • phospholipase C-activating G protein-coupled receptor signaling pathway (GO:0007200) | • positive regulation of vasoconstriction (GO:0045907) |
| • plasma membrane (GO:0005886) |
Pathways
• Adrenergic signaling in cardiomyocytes (KEGG: hsa04261)
• Calcium signaling pathway (KEGG: hsa04020)
• cGMP-PKG signaling pathway (KEGG: hsa04022)
• GPCR downstream signaling (Reactome: R-HSA-388396)
Protein Summary
The alpha-1B adrenergic receptor is a 520-amino acid protein with seven transmembrane domains typical of GPCRs. It is activated by norepinephrine and epinephrine, leading to Gq/11-mediated activation of phospholipase C, inositol trisphosphate production, and intracellular calcium release. The receptor is critical for vascular tone, prostate smooth muscle contraction, and cardiac function. Post-translational modifications include N-glycosylation and phosphorylation by GRKs, which regulate desensitization.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ADRA1B Knockout HEK293 Cell Line | EDJ-KQ1584 | Human | 147 | Details Get a Quote |
| ADRA1B Knockout A-549 Cell Line | EDJ-KQ21268 | Human | 147 | Details Get a Quote |
| ADRA1B Knockout HeLa Cell Line | EDJ-KQ21269 | Human | 147 | Details Get a Quote |
| ADRA1B Knockout HCT 116 Cell Line | EDJ-KQ69522 | Human | 147 | Details Get a Quote |
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