ADM2 (Adrenomedullin 2)
Gene encoding a peptide hormone involved in cardiovascular and metabolic regulation
Gene Information Card
| Symbol | ADM2 |
|---|---|
| Full Name | Adrenomedullin 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 22q13.33 |
| NCBI Gene ID | 79924 ncbi.nlm.nih.gov/gene/79924 |
| Ensembl ID | ENSG00000128272 |
| UniProt ID | Q7Z4H4 |
| OMIM ID | 608682 |
| HGNC ID | 16282 |
| Aliases | Intermedin, AM2 |
Description
ADM2 (adrenomedullin 2), also known as intermedin, is a protein-coding gene located on chromosome 22q13.33. The encoded preproprotein is proteolytically processed to generate a mature peptide hormone that belongs to the calcitonin/calcitonin gene-related peptide (CGRP) family. ADM2 acts through the calcitonin receptor-like receptor (CALCRL) in complex with receptor activity-modifying proteins (RAMPs) to regulate vasodilation, cardiac function, and energy homeostasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hypertension | ADM2 acts as a vasodilator; altered expression may contribute to blood pressure dysregulation. | PMID: 16959878 |
| Heart Failure | ADM2 has cardioprotective effects; reduced levels are associated with cardiac dysfunction. | PMID: 17194762 |
| Metabolic Syndrome | ADM2 modulates insulin sensitivity and energy metabolism. | PMID: 19074968 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 0.8 | Low |
| Kidney | 1.2 | Low |
| Lung | 0.5 | Low |
| Placenta | 2.3 | Medium |
| Stomach | 1.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.3 | Low expression |
| HUVEC | 1.5 | Moderate expression |
| SH-SY5Y | 0.7 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown functional effect |
| c.100C>T | synonymous | <0.01% | No predicted effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ADM2.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in ADM2.
Dominant Negative (DN)
No dominant-negative mutations reported for ADM2.
View complete mutation data：
Gene Ontology (GO)
| • GO:0005179 (hormone activity) | • GO:0005576 (extracellular region) |
| • GO:0007186 (G protein-coupled receptor signaling pathway) | • GO:0008217 (regulation of blood pressure) |
Pathways
• Calcitonin-like receptor signaling pathway (Reactome: R-HSA-419037)
• GPCR ligand binding (Reactome: R-HSA-375276)
Protein Summary
The ADM2 protein is a 148-amino-acid prepropeptide that is cleaved to produce a mature 47-amino-acid peptide (intermedin). This peptide contains a conserved disulfide bond and an amidated C-terminus, essential for receptor binding. It acts as a ligand for the calcitonin receptor-like receptor (CALCRL) in complex with RAMPs, leading to cAMP production and vasodilation. ADM2 is expressed in various tissues, including heart, kidney, and placenta, and plays roles in cardiovascular homeostasis and metabolic regulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CADM2 Knockout HEK293 Cell Line | EDJ-KQ11735 | Human | 253559 | Details Get a Quote |
| ADM2 Knockout HEK293 Cell Line | EDJ-KQ11994 | Human | 79924 | Details Get a Quote |
| ADM2 Knockout HCT 116 Cell Line | EDJ-KQ40570 | Human | 79924 | Details Get a Quote |
| ADM2 Knockout HeLa Cell Line | EDJ-KQ57255 | Human | 79924 | Details Get a Quote |
| CADM2 Knockout HeLa Cell Line | EDJ-KQ59242 | Human | 253559 | Details Get a Quote |
| ADM2 Knockout A-549 Cell Line | EDJ-KQ65767 | Human | 79924 | Details Get a Quote |
| CADM2 Knockout A-549 Cell Line | EDJ-KQ67710 | Human | 253559 | Details Get a Quote |
| CADM2 Knockout HCT 116 Cell Line | EDJ-KQ76092 | Human | 253559 | Details Get a Quote |
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