ADM (Adrenomedullin) Gene
Comprehensive gene card for ADM, encoding a potent vasodilator peptide involved in cardiovascular regulation, angiogenesis, and cancer biology.
Gene Information Card
| Symbol | ADM |
|---|---|
| Full Name | Adrenomedullin |
| Gene Type | protein-coding |
| Chromosomal Location | 11p15.4 |
| NCBI Gene ID | 133 ncbi.nlm.nih.gov/gene/133 |
| Ensembl ID | ENSG00000148926 |
| UniProt ID | P35318 |
| OMIM ID | 103275 |
| HGNC ID | 259 |
| Aliases | AM, PAMP |
Description
ADM (adrenomedullin) encodes a 52-amino acid peptide hormone initially isolated from human pheochromocytoma. It acts as a potent vasodilator, regulates blood pressure, promotes angiogenesis, and modulates cell growth. The gene is expressed in various tissues including adrenal medulla, heart, lung, kidney, and vascular endothelium. ADM signaling occurs through calcitonin receptor-like receptor (CALCRL) and receptor activity-modifying proteins (RAMPs).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hypertension | ADM overexpression leads to vasodilation and reduced blood pressure; polymorphisms associated with essential hypertension. | NCBI Gene, OMIM |
| Cardiovascular Disease | Elevated plasma ADM correlates with heart failure severity and prognosis; protective role in myocardial ischemia. | NCBI Gene, OMIM |
| Cancer (multiple types) | ADM promotes tumor angiogenesis and growth; upregulated in breast, lung, colorectal, and pancreatic cancers. | COSMIC, NCBI Gene |
| Sepsis | ADM levels increase in sepsis; acts as a compensatory vasodilator; potential biomarker. | NCBI Gene |
| Preeclampsia | Altered ADM expression implicated in placental vascular dysfunction. | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adrenal gland | 12.5 | High |
| Heart | 8.3 | Medium |
| Lung | 7.1 | Medium |
| Kidney | 6.9 | Medium |
| Liver | 2.4 | Low |
| Brain | 1.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HUVEC (endothelial) | 15.2 | High expression |
| HEK293 | 4.5 | Moderate |
| HeLa | 3.1 | Low |
| A549 (lung) | 6.8 | Medium |
| MCF7 (breast) | 5.3 | Medium |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Potential loss of start codon; functional impact unknown |
| c.148G>A (p.Ala50Thr) | missense | <0.01% | Rare variant; no known disease association |
| c.391C>T (p.Arg131Trp) | missense | <0.01% | Reported in ClinVar as uncertain significance |
| c.429_430insA | frameshift | <0.01% | Predicted loss-of-function; not observed in healthy populations |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations predicted to cause haploinsufficiency; rare in population databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported; overexpression in tumors suggests potential oncogenic role.
Dominant Negative (DN)
No dominant-negative mutations described for ADM.
View complete mutation data：
Gene Ontology (GO)
| • vasodilation | • angiogenesis |
| • hormone activity | • cell-cell signaling |
| • positive regulation of endothelial cell proliferation | • G protein-coupled receptor signaling pathway |
Pathways
• Adrenomedullin signaling through CALCRL/RAMP
• cAMP/PKA pathway
• PI3K/Akt pathway
• MAPK/ERK pathway
• VEGF signaling (angiogenesis)
Protein Summary
Adrenomedullin (P35318) is a 52-amino acid secreted peptide with an N-terminal signal peptide and a C-terminal amidation site. It contains a single disulfide bond forming a ring structure essential for receptor binding. The protein is processed from a larger precursor (proadrenomedullin) which also yields proadrenomedullin N-terminal 20 peptide (PAMP). ADM binds to the calcitonin receptor-like receptor (CALCRL) in complex with RAMP2 or RAMP3, activating Gs and leading to cAMP production. It is a potent vasodilator, inhibits apoptosis, and stimulates angiogenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ACADM Knockout HEK293 Cell Line | EDJ-KQ3144 | Human | 34 | Details Get a Quote |
| CADM3 Knockout HEK293 Cell Line | EDJ-KQ3661 | Human | 57863 | Details Get a Quote |
| CADM1 Knockout HEK293 Cell Line | EDJ-KQ3881 | Human | 23705 | Details Get a Quote |
| ADM Knockout HEK293 Cell Line | EDJ-KQ4017 | Human | 133 | Details Get a Quote |
| MYADM Knockout HEK293 Cell Line | EDJ-KQ10769 | Human | 91663 | Details Get a Quote |
| CADM4 Knockout HEK293 Cell Line | EDJ-KQ11702 | Human | 199731 | Details Get a Quote |
| ADM5 Knockout HEK293 Cell Line | EDJ-KQ11707 | Human | 199800 | Details Get a Quote |
| CADM2 Knockout HEK293 Cell Line | EDJ-KQ11735 | Human | 253559 | Details Get a Quote |
| MYADML2 Knockout HEK293 Cell Line | EDJ-KQ11792 | Human | 255275 | Details Get a Quote |
| ADM2 Knockout HEK293 Cell Line | EDJ-KQ11994 | Human | 79924 | Details Get a Quote |
| CADM1 Knockout A-549 Cell Line | EDJ-KQ26090 | Human | 23705 | Details Get a Quote |
| CADM1 Knockout HeLa Cell Line | EDJ-KQ26091 | Human | 23705 | Details Get a Quote |
| MYADM Knockout A-549 Cell Line | EDJ-KQ37086 | Human | 91663 | Details Get a Quote |
| CADM4 Knockout HCT 116 Cell Line | EDJ-KQ40040 | Human | 199731 | Details Get a Quote |
| CADM4 Knockout HeLa Cell Line | EDJ-KQ40041 | Human | 199731 | Details Get a Quote |
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