ADAMDEC1
ADAM Like Decysin 1
Gene Information Card
| Symbol | ADAMDEC1 |
|---|---|
| Full Name | ADAM like decysin 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 8p21.2 |
| NCBI Gene ID | 27299 ncbi.nlm.nih.gov/gene/27299 |
| Ensembl ID | ENSG00000134028 |
| UniProt ID | O15204 |
| OMIM ID | 606107 |
| HGNC ID | 16300 |
| Aliases | MDC, Mdc1, ADAMDEC1 |
Description
ADAMDEC1 (ADAM like decysin 1) is a protein-coding gene that encodes a member of the ADAM (a disintegrin and metalloprotease) family. The encoded protein contains a metalloprotease domain but lacks a disintegrin domain, suggesting distinct functional properties. It is involved in proteolytic processing and may play a role in immune response and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Altered expression and potential role in tumor progression | PMID: 12354777 |
| Inflammatory bowel disease | Differential expression in inflamed mucosa | PMID: 15674360 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 8.3 | Low |
| Small intestine | 6.1 | Low |
| Colon | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | Moderate expression |
| HeLa | 9.8 | Low expression |
| THP-1 | 7.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | 0.01% | Unknown functional impact |
| c.205G>A (p.Gly69Ser) | Missense | 0.005% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • metalloendopeptidase activity | • zinc ion binding |
| • proteolysis | • extracellular region |
| • membrane |
Pathways
• ADAM-mediated proteolysis
• Extracellular matrix remodeling
Protein Summary
The ADAMDEC1 protein is a secreted metalloprotease that lacks a disintegrin domain. It is involved in the cleavage of extracellular matrix components and may modulate cell adhesion and migration. Its expression is enriched in lymphoid tissues and is dysregulated in certain cancers and inflammatory conditions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ADAMDEC1 Knockout HEK293 Cell Line | EDJ-KQ8752 | Human | 27299 | Details Get a Quote |
| ADAMDEC1 Knockout HeLa Cell Line | EDJ-KQ56053 | Human | 27299 | Details Get a Quote |
| ADAMDEC1 Knockout A-549 Cell Line | EDJ-KQ64537 | Human | 27299 | Details Get a Quote |
| ADAMDEC1 Knockout HCT 116 Cell Line | EDJ-KQ72995 | Human | 27299 | Details Get a Quote |
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