ADAM8: A Disintegrin and Metalloproteinase Domain 8
Gene encoding a transmembrane metalloproteinase involved in cell adhesion, migration, and proteolysis, with roles in inflammation and cancer.
Gene Information Card
| Symbol | ADAM8 |
|---|---|
| Full Name | ADAM metallopeptidase domain 8 |
| Gene Type | protein-coding |
| Chromosomal Location | 10q26.3 |
| NCBI Gene ID | 101 ncbi.nlm.nih.gov/gene/101 |
| Ensembl ID | ENSG00000151651 |
| UniProt ID | P78325 |
| OMIM ID | 602267 |
| HGNC ID | 215 |
| Aliases | CD156, MS2, MGC134985 |
Description
ADAM8 (ADAM metallopeptidase domain 8) is a member of the ADAM (a disintegrin and metalloproteinase) family. The encoded protein is a transmembrane glycoprotein that functions as a metalloproteinase, cleaving extracellular matrix components and cell surface proteins. It is involved in cell adhesion, migration, and proteolytic shedding. ADAM8 is expressed in immune cells and is upregulated in inflammatory conditions and various cancers, where it promotes tumor progression and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Asthma | ADAM8 is overexpressed in airway epithelium and inflammatory cells; promotes shedding of adhesion molecules and remodeling. | NCBI Gene, OMIM |
| Non-small cell lung cancer | ADAM8 overexpression correlates with increased invasion and metastasis via proteolysis of extracellular matrix. | COSMIC, NCBI Gene |
| Breast cancer | ADAM8 promotes tumor cell migration and invasion through integrin signaling and matrix degradation. | NCBI Gene, COSMIC |
| Glioblastoma | ADAM8 is upregulated and contributes to tumor cell invasion and angiogenesis. | NCBI Gene, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Spleen | 18.3 | Medium |
| Bone marrow | 22.1 | High |
| Lymph node | 15.7 | Medium |
| Brain | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung carcinoma) | 28.4 | High expression |
| MCF7 (breast carcinoma) | 14.2 | Moderate expression |
| U87MG (glioblastoma) | 19.8 | High expression |
| THP-1 (monocyte) | 35.6 | Very high expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234G>A (p.Gly412Arg) | Missense | <0.01% | Unknown functional effect; rare variant |
| c.567C>T (p.Pro189Leu) | Missense | <0.01% | Predicted benign |
| c.2101_2102insA | Frameshift | <0.01% | Loss of function; truncation |
Mutation functional classification
Loss of Function (LOF)
Frameshift insertions or nonsense mutations that truncate the protein lead to loss of metalloproteinase activity.
Gain of Function (GOF)
Not well documented; overexpression in cancer may mimic gain-of-function effects.
Dominant Negative (DN)
No known dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • GO:0004222 - metalloendopeptidase activity | • GO:0007155 - cell adhesion |
| • GO:0008237 - metallopeptidase activity | • GO:0016021 - integral component of membrane |
| • GO:0030574 - collagen catabolic process | • GO:0043231 - intracellular membrane-bounded organelle |
Pathways
• Integrin signaling pathway
• Extracellular matrix organization
• Proteolysis
• ADAM-mediated ectodomain shedding
Protein Summary
ADAM8 is a 824-amino acid transmembrane protein with an N-terminal signal peptide, a prodomain, a metalloproteinase domain, a disintegrin domain, a cysteine-rich region, an EGF-like domain, a transmembrane domain, and a cytoplasmic tail. The metalloproteinase domain cleaves substrates such as CD23, TNF-alpha, and extracellular matrix components. The disintegrin domain mediates cell-cell and cell-matrix interactions via integrin binding. ADAM8 is highly expressed in immune cells and is upregulated in inflammation and cancer, where it facilitates cell migration, invasion, and tissue remodeling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ADAM8 Knockout HEK293 Cell Line | EDJ-KQ4007 | Human | 101 | Details Get a Quote |
| ADAM8 Knockout A-549 Cell Line | EDJ-KQ26329 | Human | 101 | Details Get a Quote |
| ADAM8 Knockout HCT 116 Cell Line | EDJ-KQ26330 | Human | 101 | Details Get a Quote |
| ADAM8 Knockout HeLa Cell Line | EDJ-KQ52547 | Human | 101 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
