ACTR3C
Actin Related Protein 3C
Gene Information Card
| Symbol | ACTR3C |
|---|---|
| Full Name | actin related protein 3C |
| Gene Type | protein coding |
| Chromosomal Location | 7q36.3 |
| NCBI Gene ID | 100130872 ncbi.nlm.nih.gov/gene/100130872 |
| Ensembl ID | ENSG00000215012 |
| UniProt ID | Q9UKN8 |
| OMIM ID | 613445 |
| HGNC ID | HGNC:24072 |
| Aliases | ARP3C, ARP3BETA, ARP3GAMMA |
Description
ACTR3C (actin related protein 3C) is a protein-coding gene that encodes a member of the actin-related protein (ARP) family. The encoded protein is a component of the ARP2/3 complex, which is essential for actin filament nucleation and branching, playing a key role in cell motility, cytoskeletal organization, and intracellular transport.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 3.2 | Low |
| Lung | 1.8 | Low |
| Heart | 0.9 | Not detected |
| Liver | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 8.4 | Moderate expression |
| HeLa | 5.1 | Low expression |
| K562 | 2.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function variants in ClinVar or COSMIC.
Gain of Function (GOF)
No documented gain-of-function variants.
Dominant Negative (DN)
No documented dominant-negative variants.
View complete mutation data：
Gene Ontology (GO)
| • actin filament polymerization | • structural constituent of cytoskeleton |
| • ATP binding | • actin cytoskeleton organization |
Pathways
• Arp2/3 complex-mediated actin nucleation
• Regulation of actin cytoskeleton
Protein Summary
The ACTR3C protein is a 418-amino acid actin-related protein that forms part of the ARP2/3 complex. It shares structural similarity with actin and is involved in nucleating new actin filaments from existing ones, contributing to cell shape, motility, and division.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ACTR3C Knockout HEK293 Cell Line | EDJ-KQ12276 | Human | 653857 | Details Get a Quote |
| ACTR3C Knockout HeLa Cell Line | EDJ-KQ41081 | Human | 653857 | Details Get a Quote |
| ACTR3C Knockout A-549 Cell Line | EDJ-KQ69138 | Human | 653857 | Details Get a Quote |
| ACTR3C Knockout HCT 116 Cell Line | EDJ-KQ77490 | Human | 653857 | Details Get a Quote |
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