ACTR3B
Actin Related Protein 3B
Gene Information Card
| Symbol | ACTR3B |
|---|---|
| Full Name | Actin Related Protein 3B |
| Gene Type | protein-coding |
| Chromosomal Location | 7q36.3 |
| NCBI Gene ID | 57180 ncbi.nlm.nih.gov/gene/57180 |
| Ensembl ID | ENSG00000106571 |
| UniProt ID | Q9P1U1 |
| OMIM ID | 608732 |
| HGNC ID | 17025 |
| Aliases | ARP3B, ARP3, ARP3BETA, ARP3-BETA |
Description
ACTR3B encodes a member of the actin-related protein (ARP) family, which is a component of the ARP2/3 complex. This complex is essential for the nucleation of actin filaments and regulation of actin polymerization, playing a key role in cell motility, shape, and division. ACTR3B is specifically expressed in certain tissues and is implicated in cancer progression and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Overexpression of ACTR3B enhances ARP2/3 complex activity, promoting invasive cell migration and metastasis. | PMID: 23382250; COSMIC |
| Pancreatic Cancer | ACTR3B upregulation correlates with increased tumor cell invasion and poor prognosis. | PMID: 25656897; COSMIC |
| Colorectal Cancer | ACTR3B expression is associated with lymph node metastasis and advanced stage. | PMID: 27323851; COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Breast | 15.2 nTPM | Medium |
| Pancreas | 12.8 nTPM | Medium |
| Colon | 10.5 nTPM | Medium |
| Lung | 8.3 nTPM | Low |
| Liver | 5.1 nTPM | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 18.4 nTPM | High expression |
| PANC-1 (pancreatic cancer) | 14.7 nTPM | High expression |
| HCT116 (colorectal cancer) | 11.2 nTPM | Medium expression |
| A549 (lung cancer) | 7.9 nTPM | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.1% (COSMIC) | Unknown functional impact |
| c.452A>G (p.Asn151Ser) | Missense | <0.1% (COSMIC) | Unknown functional impact |
| c.788G>A (p.Arg263Gln) | Missense | <0.1% (COSMIC) | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
Overexpression in cancers suggests potential gain-of-function role in cell migration.
Dominant Negative (DN)
No dominant-negative mutations documented.
View complete mutation data：
Gene Ontology (GO)
| • plasma membrane (GO:0005886) | • cytoskeleton (GO:0005856) |
| • actin filament polymerization (GO:0030041) | • Arp2/3 complex-mediated actin nucleation (GO:0034314) |
| • protein binding (GO:0005515) |
Pathways
• hsa04810 - Regulation of actin cytoskeleton
• hsa05200 - Pathways in cancer
• hsa05205 - Proteoglycans in cancer
Protein Summary
ACTR3B is a 418-amino acid protein (UniProt Q9P1U1) that forms part of the ARP2/3 complex. It shares high homology with ACTR3 (ARP3) and is involved in actin filament branching. The protein is localized to the cytoplasm and cell cortex, and its expression is enriched in tissues with high motility demands. Overexpression in multiple cancers suggests a role in tumor invasion and metastasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ACTR3B Knockout HEK293 Cell Line | EDJ-KQ12275 | Human | 57180 | Details Get a Quote |
| ACTR3B Knockout A-549 Cell Line | EDJ-KQ41078 | Human | 57180 | Details Get a Quote |
| ACTR3B Knockout HCT 116 Cell Line | EDJ-KQ41079 | Human | 57180 | Details Get a Quote |
| ACTR3B Knockout HeLa Cell Line | EDJ-KQ39836 | Human | 57180 | Details Get a Quote |
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