ACOT11: Acyl-CoA Thioesterase 11
Gene encoding a peroxisomal acyl-CoA thioesterase involved in lipid metabolism and fatty acid oxidation.
Gene Information Card
| Symbol | ACOT11 |
|---|---|
| Full Name | Acyl-CoA Thioesterase 11 |
| Gene Type | Protein coding |
| Chromosomal Location | 1p36.31 |
| NCBI Gene ID | 26027 ncbi.nlm.nih.gov/gene/26027 |
| Ensembl ID | ENSG00000162390 |
| UniProt ID | Q8WXI4 |
| OMIM ID | 614299 |
| HGNC ID | 23457 |
| Aliases | STARD14, THEA, FLJ22662 |
Description
ACOT11 encodes a member of the acyl-CoA thioesterase family, which catalyzes the hydrolysis of acyl-CoAs to free fatty acids and coenzyme A. The protein localizes to peroxisomes and is involved in lipid metabolism, particularly in the regulation of fatty acid oxidation and cellular lipid homeostasis. It is also known as STARD14 due to its START domain.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | ACOT11 may influence lipid storage and energy expenditure through modulation of acyl-CoA levels. | Limited evidence from GWAS and expression studies; not yet clinically validated. |
| Metabolic syndrome | Altered ACOT11 expression could affect fatty acid oxidation and insulin sensitivity. | Association studies; functional data in model organisms. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Adipose tissue | 8.3 | Low |
| Kidney | 6.7 | Low |
| Small intestine | 4.2 | Low |
| Heart | 3.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.2 | Hepatocellular carcinoma cell line |
| HEK293 | 2.1 | Embryonic kidney cells |
| HeLa | 1.8 | Cervical cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.502C>T (p.Arg168Trp) | Missense | 0.0002 (gnomAD) | Unknown functional impact; not reported in ClinVar |
| c.1015G>A (p.Gly339Ser) | Missense | 0.0001 (gnomAD) | Predicted benign by in silico tools |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No evidence for gain-of-function mutations.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
| • GO:0003986 - acetyl-CoA hydrolase activity | • GO:0016290 - palmitoyl-CoA hydrolase activity |
| • GO:0005777 - peroxisome | • GO:0006631 - fatty acid metabolic process |
| • GO:0055089 - fatty acid homeostasis |
Pathways
• Fatty acid metabolism (Reactome: R-HSA-8978868)
• Peroxisomal lipid metabolism (Reactome: R-HSA-8978868)
Protein Summary
ACOT11 is a 439-amino acid peroxisomal acyl-CoA thioesterase with a START domain. It hydrolyzes medium- to long-chain acyl-CoAs, regulating intracellular fatty acid levels. The protein is expressed primarily in liver and adipose tissue, suggesting a role in energy metabolism.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ACOT11 Knockout HEK293 Cell Line | EDJ-KQ7687 | Human | 26027 | Details Get a Quote |
| ACOT11 Knockout A-549 Cell Line | EDJ-KQ34390 | Human | 26027 | Details Get a Quote |
| ACOT11 Knockout HCT 116 Cell Line | EDJ-KQ34391 | Human | 26027 | Details Get a Quote |
| ACOT11 Knockout HeLa Cell Line | EDJ-KQ34392 | Human | 26027 | Details Get a Quote |
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