ACKR2 (Atypical Chemokine Receptor 2)
Atypical chemokine receptor involved in chemokine scavenging and regulation of inflammation
Gene Information Card
| Symbol | ACKR2 |
|---|---|
| Full Name | Atypical Chemokine Receptor 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 3p22.1 |
| NCBI Gene ID | 1238 ncbi.nlm.nih.gov/gene/1238 |
| Ensembl ID | ENSG00000144648 |
| UniProt ID | O00590 |
| OMIM ID | 602648 |
| HGNC ID | 1615 |
| Aliases | D6, CCBP2, CMKBR9, CCR10, CC-CKR-10 |
Description
ACKR2 (Atypical Chemokine Receptor 2) encodes a protein that belongs to the atypical chemokine receptor family. It is a scavenger receptor for inflammatory CC chemokines, internalizing and degrading them without activating typical G-protein signaling. ACKR2 is expressed on lymphatic endothelial cells, placental trophoblasts, and leukocytes, playing a key role in regulating inflammation, immune responses, and placental development.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory disorders | ACKR2 scavenges inflammatory chemokines, reducing leukocyte infiltration; loss of function leads to exacerbated inflammation. | PMID: 16920917, 18490741 |
| Preeclampsia | Reduced ACKR2 expression in placenta may impair chemokine clearance, contributing to maternal systemic inflammation. | PMID: 22194618 |
| Cancer (e.g., breast, colorectal) | ACKR2 expression in tumor microenvironment modulates chemokine levels, affecting immune cell recruitment and tumor progression. | PMID: 24658312, 26015514 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Placenta | 15.2 | High |
| Lymph node | 8.7 | Medium |
| Spleen | 6.4 | Medium |
| Lung | 3.1 | Low |
| Skin | 2.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HUVEC (umbilical vein endothelial) | 12.5 | High expression |
| THP-1 (monocytic) | 7.8 | Medium expression |
| HeLa (cervical) | 2.1 | Low expression |
| MCF7 (breast) | 1.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Likely loss of start codon; predicted loss of function |
| c.520C>T (p.Arg174Trp) | missense | <0.01% | Unknown significance; located in extracellular domain |
| c.1018G>A (p.Gly340Ser) | missense | <0.01% | Unknown significance; located in cytoplasmic tail |
Mutation functional classification
Loss of Function (LOF)
Loss-of-function mutations in ACKR2 impair chemokine scavenging, leading to excessive inflammation and potential contribution to inflammatory diseases.
Gain of Function (GOF)
No gain-of-function mutations have been reported for ACKR2.
Dominant Negative (DN)
No dominant-negative mutations have been described for ACKR2.
View complete mutation data：
Gene Ontology (GO)
| • G-protein coupled receptor activity | • chemokine binding |
| • chemokine receptor activity | • signal transduction |
| • inflammatory response | • chemokine-mediated signaling pathway |
| • receptor-mediated endocytosis | • negative regulation of leukocyte chemotaxis |
Pathways
• Chemokine signaling pathway
• Class A/1 (Rhodopsin-like receptors)
• Scavenging of chemokines
Protein Summary
ACKR2 is a 384-amino acid atypical chemokine receptor with seven transmembrane domains. It lacks the DRYLAIV motif required for G-protein coupling, preventing classical signaling. Instead, it constitutively internalizes and degrades inflammatory CC chemokines (e.g., CCL2, CCL3, CCL4, CCL5), acting as a decoy receptor. The protein is expressed on lymphatic endothelium, placental syncytiotrophoblasts, and subsets of leukocytes, where it modulates chemokine gradients and immune cell trafficking. ACKR2 is critical for resolving inflammation and maintaining immune homeostasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ACKR2 Knockout HEK293 Cell Line | EDJ-KQ4299 | Human | 1238 | Details Get a Quote |
| ACKR2 Knockout HeLa Cell Line | EDJ-KQ52937 | Human | 1238 | Details Get a Quote |
| ACKR2 Knockout A-549 Cell Line | EDJ-KQ61404 | Human | 1238 | Details Get a Quote |
| ACKR2 Knockout HCT 116 Cell Line | EDJ-KQ69899 | Human | 1238 | Details Get a Quote |
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