ABCC5: ATP Binding Cassette Subfamily C Member 5
Multidrug Resistance-Associated Protein 5 (MRP5) - A Key Transporter in Drug Disposition and Cancer Chemoresistance
Gene Information Card
| Symbol | ABCC5 |
|---|---|
| Full Name | ATP Binding Cassette Subfamily C Member 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 3q27.1 |
| NCBI Gene ID | 10057 ncbi.nlm.nih.gov/gene/10057 |
| Ensembl ID | ENSG00000114770 |
| UniProt ID | O15440 |
| OMIM ID | 605251 |
| HGNC ID | 56 |
| Aliases | MRP5, MOAT-C, MOATC, ABC33, SMRP, pABC11 |
Description
ABCC5 (ATP Binding Cassette Subfamily C Member 5) encodes multidrug resistance-associated protein 5 (MRP5), a member of the ATP-binding cassette (ABC) transporter superfamily. MRP5 functions as an organic anion transporter, mediating the efflux of cyclic nucleotides (cAMP, cGMP) and various xenobiotics, including nucleoside analogs and chemotherapeutic agents. It is implicated in multidrug resistance in cancer and plays roles in cellular signaling and detoxification.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (multidrug resistance) | Overexpression of ABCC5 increases efflux of chemotherapeutic drugs (e.g., 5-fluorouracil, methotrexate), reducing intracellular drug accumulation and conferring resistance. | PMID: 12695511, PMID: 15373890 |
| Cystic fibrosis | ABCC5 may modulate CFTR activity via cGMP transport, but direct disease association is not well established. | PMID: 15689490 |
| Gout | ABCC5 polymorphisms are associated with urate transport and serum uric acid levels, contributing to hyperuricemia. | PMID: 23263486 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.3 | Medium |
| Kidney | 9.8 | Medium |
| Small intestine | 8.5 | Medium |
| Brain | 6.2 | Low |
| Lung | 5.1 | Low |
| Heart | 3.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | Cervical cancer cell line |
| HepG2 | 11.7 | Hepatocellular carcinoma |
| A549 | 8.9 | Lung adenocarcinoma |
| MCF7 | 6.3 | Breast cancer |
| K562 | 4.8 | Leukemia |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1519G>A (p.Gly507Arg) | Missense | 0.01% (gnomAD) | Reduced transport activity; associated with altered drug response |
| c.2125C>T (p.Arg709Trp) | Missense | 0.005% (gnomAD) | Unknown functional effect |
| c.3466G>A (p.Gly1156Ser) | Missense | 0.02% (gnomAD) | Potential loss of function |
Mutation functional classification
Loss of Function (LOF)
Missense variants (e.g., p.Gly507Arg) that impair ATP binding or substrate transport reduce efflux capacity.
Gain of Function (GOF)
Not well documented; overexpression in tumors is associated with increased drug efflux but not due to activating mutations.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • ATP binding (GO:0005524) | • ATPase activity (GO:0016887) |
| • ABC-type transporter activity (GO:0042626) | • xenobiotic transmembrane transporter activity (GO:0008559) |
| • cGMP transmembrane transporter activity (GO:0015238) | • cAMP transmembrane transporter activity (GO:0015239) |
| • plasma membrane (GO:0005886) | • integral component of membrane (GO:0016021) |
| • response to drug (GO:0042493) |
Pathways
• ABC transporters (KEGG: hsa02010)
• Drug metabolism - other enzymes (KEGG: hsa00983)
• cGMP-PKG signaling pathway (KEGG: hsa04022)
• Glutathione metabolism (KEGG: hsa00480)
Protein Summary
Multidrug resistance-associated protein 5 (MRP5) is a 1437-amino acid transmembrane protein with two nucleotide-binding domains (NBDs) and two membrane-spanning domains (MSDs). It functions as an ATP-dependent efflux pump for organic anions, cyclic nucleotides, and conjugated xenobiotics. MRP5 is expressed in multiple tissues, including liver, kidney, and intestine, and is upregulated in various cancers, contributing to chemoresistance. Its structure includes a unique N-terminal extension compared to other MRPs, and it is involved in cellular signaling via cGMP transport.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ABCC5 Knockout HEK293 Cell Line | EDJ-KQ6879 | Human | 10057 | Details Get a Quote |
| ABCC5 Knockout A-549 Cell Line | EDJ-KQ30096 | Human | 10057 | Details Get a Quote |
| ABCC5 Knockout HCT 116 Cell Line | EDJ-KQ31471 | Human | 10057 | Details Get a Quote |
| ABCC5 Knockout HeLa Cell Line | EDJ-KQ31472 | Human | 10057 | Details Get a Quote |
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