ABCC10: ATP Binding Cassette Subfamily C Member 10
Multidrug Resistance-Associated Protein 7 (MRP7) – Transporter, Pharmacogenomics, and Cancer Resistance
Gene Information Card
| Symbol | ABCC10 |
|---|---|
| Full Name | ATP Binding Cassette Subfamily C Member 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 6p21.1 |
| NCBI Gene ID | 89845 ncbi.nlm.nih.gov/gene/89845 |
| Ensembl ID | ENSG00000124562 |
| UniProt ID | Q5T3U5 |
| OMIM ID | 612509 |
| HGNC ID | 14640 |
| Aliases | MRP7, EST182763, SIMRP7 |
Description
ABCC10 (ATP Binding Cassette Subfamily C Member 10) encodes multidrug resistance-associated protein 7 (MRP7), an ATP-dependent transporter of organic anions and xenobiotics. MRP7 is involved in the efflux of chemotherapeutic agents (e.g., taxanes, vinca alkaloids, epothilones) and contributes to multidrug resistance in cancer cells. The gene is located on chromosome 6p21.1 and is expressed in various tissues including liver, kidney, and intestine. Polymorphisms and altered expression of ABCC10 have been associated with drug response and toxicity.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (multidrug resistance) | Overexpression of MRP7 increases efflux of chemotherapeutic drugs (e.g., paclitaxel, docetaxel, vincristine), reducing intracellular drug accumulation and efficacy. | ClinVar, COSMIC, PubMed |
| Cholestasis | MRP7 transports bile acid conjugates; dysfunction may impair bile flow. | UniProt, OMIM |
| Drug-induced toxicity | Genetic variants in ABCC10 alter transporter activity, affecting drug clearance and risk of adverse reactions (e.g., neuropathy with taxanes). | ClinVar, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 9.8 | Medium |
| Small intestine | 7.2 | Low |
| Colon | 6.1 | Low |
| Lung | 4.3 | Low |
| Breast | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 8.5 | Cervical cancer cell line |
| MCF7 | 7.1 | Breast cancer cell line |
| A549 | 6.8 | Lung cancer cell line |
| HepG2 | 11.2 | Hepatocellular carcinoma cell line |
| Caco-2 | 9.0 | Colorectal adenocarcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1684C>T (p.Arg562Cys) | Missense | 0.02% (gnomAD) | Reduced transport activity; associated with altered drug response. |
| c.2008G>A (p.Val670Met) | Missense | 0.01% (gnomAD) | Unknown functional effect. |
| c.3529G>A (p.Ala1177Thr) | Missense | 0.005% (gnomAD) | Potential impact on substrate specificity. |
Mutation functional classification
Loss of Function (LOF)
c.1684C>T (p.Arg562Cys) reduces transport of taxanes and vinca alkaloids in vitro.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
Not described for ABCC10.
View complete mutation data：
Gene Ontology (GO)
| • ATP binding (GO:0005524) | • ATPase activity coupled to transmembrane movement of substances (GO:0042626) |
| • xenobiotic transmembrane transporter activity (GO:0008559) | • plasma membrane (GO:0005886) |
| • response to drug (GO:0042493) | • transport (GO:0006810) |
Pathways
• ABC transporters (KEGG: hsa02010)
• Multidrug resistance (Reactome: R-HSA-382556)
• Transport of organic anions (Reactome: R-HSA-879518)
Protein Summary
MRP7 (ABCC10) is a 1,464-amino acid transmembrane protein belonging to the ABC transporter family. It contains two nucleotide-binding domains (NBDs) and two transmembrane domains (TMDs), typical of full transporters. MRP7 mediates ATP-dependent efflux of organic anions, including glutathione and glucuronide conjugates, and confers resistance to several chemotherapeutic agents. It is expressed in epithelial tissues and plays a role in drug disposition and detoxification.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ABCC10 Knockout HEK293 Cell Line | EDJ-KQ10524 | Human | 89845 | Details Get a Quote |
| ABCC10 Knockout A-549 Cell Line | EDJ-KQ37942 | Human | 89845 | Details Get a Quote |
| ABCC10 Knockout HCT 116 Cell Line | EDJ-KQ37943 | Human | 89845 | Details Get a Quote |
| ABCC10 Knockout HeLa Cell Line | EDJ-KQ36652 | Human | 89845 | Details Get a Quote |
