AADACL4
Arylacetamide Deacetylase Like 4
Gene Information Card
| Symbol | AADACL4 |
|---|---|
| Full Name | Arylacetamide Deacetylase Like 4 |
| Gene Type | Protein coding |
| Chromosomal Location | 1p36.21 |
| NCBI Gene ID | 343066 ncbi.nlm.nih.gov/gene/343066 |
| Ensembl ID | ENSG00000187742 |
| UniProt ID | Q5VUY2 |
| OMIM ID | 614592 |
| HGNC ID | 26959 |
| Aliases | FLJ23577, MGC15619 |
Description
AADACL4 (arylacetamide deacetylase like 4) is a protein-coding gene located on chromosome 1p36.21. It encodes a member of the serine hydrolase family, potentially involved in the metabolism of xenobiotics and endogenous lipids. The gene is expressed in various tissues, with highest levels in the liver and kidney. Limited functional studies suggest a role in deacetylation reactions, but the precise physiological substrates remain to be fully characterized.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations in OMIM or ClinVar | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Low |
| Testis | 5.1 | Low |
| Lung | 3.2 | Low |
| Brain | 1.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.2 | Hepatocellular carcinoma cell line |
| HEK293 | 2.1 | Embryonic kidney cells |
| A549 | 1.8 | Lung carcinoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • GO:0016787 hydrolase activity | • GO:0052689 carboxylic ester hydrolase activity |
| • GO:0005737 cytoplasm |
Pathways
• No curated pathways in Reactome or KEGG
Protein Summary
The AADACL4 protein (UniProt Q5VUY2) is a 432-amino acid serine hydrolase with a predicted molecular weight of 48.5 kDa. It contains a conserved GXSXG motif characteristic of the serine esterase/lipase family. The protein is localized to the cytoplasm and may participate in the hydrolysis of ester or amide bonds in small molecules. Structural predictions indicate a typical alpha/beta hydrolase fold. No crystal structure is currently available.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| AADACL4 Knockout HEK293 Cell Line | EDJ-KQ12241 | Human | 343066 | Details Get a Quote |
| AADACL4 Knockout HeLa Cell Line | EDJ-KQ59743 | Human | 343066 | Details Get a Quote |
| AADACL4 Knockout A-549 Cell Line | EDJ-KQ68212 | Human | 343066 | Details Get a Quote |
| AADACL4 Knockout HCT 116 Cell Line | EDJ-KQ76588 | Human | 343066 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
