AADACL3
Arylacetamide Deacetylase Like 3
Gene Information Card
| Symbol | AADACL3 |
|---|---|
| Full Name | arylacetamide deacetylase like 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.21 |
| NCBI Gene ID | 126767 ncbi.nlm.nih.gov/gene/126767 |
| Ensembl ID | ENSG00000187742 |
| UniProt ID | Q5VUY2 |
| OMIM ID | 614488 |
| HGNC ID | 28608 |
| Aliases | FLJ23588, MGC131831 |
Description
AADACL3 (arylacetamide deacetylase like 3) is a protein-coding gene located on chromosome 1p36.21. It encodes a member of the arylacetamide deacetylase family, which may be involved in the metabolism of xenobiotics and endogenous compounds. The protein is predicted to have esterase/lipase activity.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease associations curated | Not applicable | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 0.8 | Low |
| Kidney | 0.5 | Low |
| Testis | 0.3 | Low |
| Brain | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 0.6 | Low expression |
| HEK293 | 0.2 | Low expression |
| K562 | 0.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • GO:0016787 hydrolase activity | • GO:0005737 cytoplasm |
Protein Summary
The AADACL3 protein (UniProt Q5VUY2) is a 418-amino acid enzyme with predicted hydrolase activity. It belongs to the arylacetamide deacetylase family and is localized in the cytoplasm. Its specific substrates and biological functions remain largely uncharacterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| AADACL3 Knockout HEK293 Cell Line | EDJ-KQ8202 | Human | 126767 | Details Get a Quote |
| AADACL3 Knockout HeLa Cell Line | EDJ-KQ58187 | Human | 126767 | Details Get a Quote |
| AADACL3 Knockout A-549 Cell Line | EDJ-KQ66677 | Human | 126767 | Details Get a Quote |
| AADACL3 Knockout HCT 116 Cell Line | EDJ-KQ75091 | Human | 126767 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
