AADACL2 Gene
Arylacetamide Deacetylase Like 2
Gene Information Card
| Symbol | AADACL2 |
|---|---|
| Full Name | Arylacetamide Deacetylase Like 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 3q25.1 |
| NCBI Gene ID | 344752 ncbi.nlm.nih.gov/gene/344752 |
| Ensembl ID | ENSG00000186184 |
| UniProt ID | Q6P3U7 |
| OMIM ID | 614482 |
| HGNC ID | 28294 |
| Aliases | FLJ38973, MGC131895 |
Description
AADACL2 (arylacetamide deacetylase like 2) is a protein-coding gene located on chromosome 3q25.1. It belongs to the serine hydrolase family and is predicted to have hydrolase activity, potentially involved in xenobiotic metabolism. The gene is expressed in various tissues, with highest levels in liver and kidney. Its biological function and disease associations are not fully characterized.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Testis | 5.1 | Low |
| Lung | 3.2 | Low |
| Brain | 1.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 10.2 | Hepatocellular carcinoma cell line |
| HEK293 | 4.5 | Embryonic kidney cell line |
| A549 | 2.1 | Lung carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • GO:0016787 (hydrolase activity) | • GO:0005737 (cytoplasm) |
Protein Summary
The AADACL2 protein (UniProt Q6P3U7) is a 421-amino acid serine hydrolase with a predicted molecular mass of ~47 kDa. It contains a catalytic triad typical of serine esterases. Its precise substrate specificity and physiological role remain unknown, but it may participate in the deacetylation of arylacetamide compounds.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| AADACL2 Knockout HEK293 Cell Line | EDJ-KQ12240 | Human | 344752 | Details Get a Quote |
| AADACL2 Knockout HeLa Cell Line | EDJ-KQ59775 | Human | 344752 | Details Get a Quote |
| AADACL2 Knockout A-549 Cell Line | EDJ-KQ68244 | Human | 344752 | Details Get a Quote |
| AADACL2 Knockout HCT 116 Cell Line | EDJ-KQ76620 | Human | 344752 | Details Get a Quote |
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