lentiCRISPR v3-CASP3-sgRNA2-puro
EDITGENE guarantees lentiCRISPR v3-CASP3-sgRNA2-puro plasmid has passed QC, endotoxin-free, and project validated. more
Cat.No: EDV3581
Quantity
EDITGENE guarantees lentiCRISPR v3-CASP3-sgRNA2-puro plasmid has passed QC, endotoxin-free, and project validated.
| Plasmid Resistance | Amp |
|---|---|
| Type | KO |
| Selection Marker | puro |
| Tag | / |
| Gene ID | |
| Gene | CASP3 |
| Gene Synonyms | CPP32|CPP32B|SCA-1 |
| Summary |
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]
|
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
Storage
Store at -20 ºC for short term. -80 ºC for long term preservation.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.
