TurboMice™: Accelerating the Future of Mouse Model Creation
With TurboMice™, we are revolutionizing the world of genetic engineering. Our optimized tetraploid complementation technology allows for the rapid creation of next-generation mouse models with unprecedented precision. Designed for researchers in universities, research institutes, hospitals, and pharmaceutical companies, TurboMice™ cuts the time and complexity of traditional mouse model generation, enabling quicker results with enhanced accuracy.
Our platform excels in the creation of multi-locus gene-edited mouse models, offering the ability to edit up to three genes simultaneously. With TurboMice™, what once took up to two years can now be accomplished in just 3–5 months, enabling faster and more efficient scientific discovery.
How TurboMice™ Revolutionize the Creation of Next-Generation Mouse Models:
TurboMice™ stands at the forefront of next-generation mouse model creation, providing unmatched efficiency and precision in genetic engineering. By harnessing optimized tetraploid complementation technology, we offer researchers the ability to generate complex mouse models faster and more accurately than ever before. With the ability to simultaneously edit multiple genes, TurboMice™ eliminates traditional bottlenecks like breeding and screening, dramatically reducing model development time. This revolutionary approach enables accelerated research and opens the door to more advanced and reliable scientific discoveries.
Utilizing TurboMice™ technology, the model preparation period can be cut to as short as 2-4 months.
TurboMice™
technology offers more flexibility with a variety of inbred and outbred strains to choose
from (including
Balb /c, 129, C57BL/6
, etc.).
Top-level gene editing technology:
In situ precise gene editing with precise gene expression levels and accurate tissue specificity.
Expression Level Improved:
MingCeler's proprietar EnhancerPlus platform can help our customers improve the expression levels of humanized genes.
TurboMice™ technology gives the advantages of high accuracy in inserting location, long fragment insertion, and multiple genetically modified loci, with no allelic segregation issues.
>20kb long fragment:
Quick Batch
Utilizing TurboMice™ technology, the model preparation period can be cut to as short as 2-4 months.
In 2020, the TurboMice™ technology was leveraged to rapidly produce homozygous humanized ACE2 mice in March and then produce more than 500 homozygous humanized ACE2 mice before October for COVID-19 drug and vaccine studies.
Flexible Strain Selection
TurboMice™
technology offers more flexibility with a variety of inbred and outbred strains to choose
from (including
Balb /c, 129, C57BL/6
, etc.).
Maintain Genetic Integrity
In Situ Precise Gene Editing
Top-level gene editing technology:
Unique EnhancerPlus Analysis Platform
Expression Level Improved:
Fast Iteration:
In 2020, MingCeler has upgraded the ACE2 humanized mouse model through four iterations via EnhancerPlus optimization and codon optimization, with the expression level of humanized ACE2 eventually reaching near the endogenous expression of mouse ACE2.
Multi-Locus Gene Editing
TurboMice™ technology gives the advantages of high accuracy in inserting location, long fragment insertion, and multiple genetically modified loci, with no allelic segregation issues.
Long Fragment Gene Editing
>20kb long fragment:
TurboMice™ technology enables precise gene editing of long fragments of >20kb.
Application:
Facilitating the rapid production of complex models such as humanization, conditional knock-out (CKO), and large fragment knock-in (KI).
Facilitating the rapid production of complex models such as humanization, conditional knock-out (CKO), and large fragment knock-in (KI).
